Nucleic Acid Synthesis Inhibitors Flashcards

0
Q

MOA of Trimethoprim

A

Srlective inhibitor of bacterial dihydrofolate reductase

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1
Q

MOA of Sulfonamides

A

Becteriostatic inhibitors of folic acid synthesis by competitively binding to dihydropteroate synthase

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2
Q

Short acting sulfonamide

A

Sulfisoxazole

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3
Q

Intermediate acting sulfonamide

A

Sulfamethoxazole

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4
Q

Long acting sulfonamide

A

Sulfadoxine

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5
Q

MOA of Fluoroquinolones

A

Interferes with topoisomerase II (DNA gyrase) in Gm (-) bacteria and topoisomerase IV in Gm (+) bacteria

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