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Pharmacology > Antifungal and Antiviral > Flashcards

Antifungal and Antiviral Flashcards

0
Q

Inhibits thymidilate synthase

A

Flucytosine

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1
Q

Binds to ergosterol in fungal cell membranes

A

Amphotericin B

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2
Q

Treatment for madura foot

A

Flucytosine

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3
Q

MOA of azole family

A

Inhibit fungal P-450 dependent enzymes blocking ergosterol synthesis

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4
Q

Treatment for candidiasis

A

Fluconazole

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5
Q

Common adverse effects of azoles

A

GI disturbance (vomiting, diarrhea), rash and hepatotoxicity

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6
Q

Inhibits beta-glucan synthase decreasing cell wall synthesis

A

Caspofungin

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7
Q

Treatment of dermatophytosis

A

Griseofulvin

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8
Q

Which of the following systemic antifungal is contraindicated to porphyria?

A. Griseofulvin
B. Terbinafine
C. Nystatin
D. Clotrimazole

A

A. Griseofulvin

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9
Q

Squalene oxidase inhibitor

A

Terbinafine

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10
Q

Antifungal that causes severe nephrotoxicity

A

Nystatin

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11
Q

Anti-herpes that is activated by viral thymidine kinase to inhibit viral DNA polymerase

A

Acyclovir

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12
Q

Inhibits viral DNA polymerase, causing chain termination

A

Anti-CMV

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13
Q

Most common cause of blindness in AIDS

A

CMV retinitis

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14
Q

Inhibits viral RNA polymerase, DNA polymerase, and HIV reverse transcriptase

A

Foscarnet

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15
Q

Inhibit HIV reverse transcriptase after phosphorylation

A

Nucleoside reverse transcriptase (NRTI)

16
Q

Examples of NRTI

A 
Abacavir
Didanosine
Lamivudine
Zidovudine
Tenofovir
Stavudine
17
Q

Inhibits HIV reverse transcriptase without requiring phosphorylation

A

Non-Nuvleoside Reverse Transcriptase Inhibitor (NNRTI)

18
Q

Examples of NNRTI

A

Delavirdine
Efavirenz
Etravirine
Nevirapine

19
Q

Anti HIV drug class given for prevention of maternal-fetal HIV transmission

A

NRTI

20
Q

Inhibit viral protein processing

A

Protease inhibitors

21
Q

Examples of protease inhibitors

A

All that ends with -navir

22
Q

Binds to gp41 subunit of viral envelope glycoprotein preventing fusion of viral and cellular membranes

A

Enfuvirtide (Fusion Inhibitor)

23
Q

Blocks viral attachment via transmembrane chemokine receptor CCR5

A

Maraviroc (CCR5 receptor antagonist)

24
Q

Inhibit early step replication and prevent uncoating by binding to M2 proton channels

A

Amantadine

25
Q

Uses of amantadine

A

Influenza A and rubella

26
Q

Inhibits neuraminidase

A

Oseltamivir and Zanamivir

27
Q

Drug of choice for influenza, including H1N1

A

Oseltamivir

28
Q

Degrades viral RNA via activation of host cell RNAase (ribonuclease)

A

Interferon-alpha

29
Q

Inhibits HBV DNA polymerase

A

Lamivudine

30
Q

Inhibits guanosine triphosphate formation

A

Ribavirin

31
Q

Contraindications to interferon-alpha

A

Pregnancy
Autoimmune disease
Cardiac arrhythmias

Pharmacology (10 decks)

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