Nucleic Acid & Heredity Flashcards
Evident or manifested in majority of the offspring or
children
Dominant
May be seen only in a minority of offspring
Recessive
Physical and observable aspects of heredity
Phenotype
Non-observable and non-physical aspects of heredity
Genotype
Obligate intracellular organisms
Viruses
Viral viruses
Bacteriophage
DNA or RNA viruses
Animal viruses
Acidic, Soluble in bases (forms salts), Precipitated by acetic acid; redissolved by dilute HCl
•Not coagulated by heat
Nucleoproteins
Causes DNA to unwind
Helicase
Joins Okazaki fragments together
Ligase
Catalyzes the formation of new phosphodiester linkage between the nucleotide and the growing DNA strand
Polymerase
Change in the DNA base sequence that alters the structure and function of the protein
Genetic Mutation
Replaces one base in DNA with a different base
Substitution
Inserts or deletes a base in the DNA sequence
Frame Shift Mutation
Leading cause of mental retardation (1:800)
Trisomy 21
Defective hemoglobin gene on
Chromosome 11, Priapism
Sickle Cell Anemia
Physical characteristics of Down syndrome
Almond shaped eyes
Absence of transferase enzyme for the metabolism of galactose-1-phosphate that may lead to cataract formation and mental retardation
Galactosemia
Most common inherited disease of the lungs
Cystic Fibrosis
Mutation on the Chromosome 19! Too much high cholesterol levels , Early CHD
Familial Hypercholesterolemia
Poor blood coagulation, AKA Royal Blood Disease
Hemophilia