Nu2003 Flashcards

1
Q

Discuss drug admin under code of conduct 2014

A

Ensure medication administered safely and effectively. Nurses must have appropriate knowledge, skills, competence and up to date knowledge. Responsible for assessing the patients condition and monitoring their response as well as identifying and reporting any ADR’s

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2
Q

Discuss drug admin under scope of practice 2015

A

Responsibilities include assessing patient’s medication history, ensuring its prescribed correctly and checking medication for accuracy and suitability. Ensure patient understands the purpose, dose, and side effects.

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3
Q

Discuss drug admin under guidelines to medication management 2020

A

Provides detailed guidelines on medication admin including storage, handling and prep. Including medication errors, reporting ADR’s and managing medication related incidents

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4
Q

Drug admin procedure

A

Check prescription, question cardex, quiet clean space, wash hands, check time of last admin, check pt name, get from double locked press, stock count w register, check label, dose, expiry, record in CD register, prescription dose against container, correct pt, admin, correct route, dose, time, patient. Record in register and medication notes, patient comfort, assess for ADR or effectiveness, dispose sharps

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5
Q

Importance of pain assessment

A

Vital to ensure patient receives appropriate pain relief, prevents under/over treated pain, develops effective pain management plan incl pharma and non pharma, improves patient outcomes, and quality of life

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6
Q

Discuss comprehensive pain assessment

A

P: provoking factors; causes/ what increased pain, Q: quality; characteristics, throbbing, stabbing, dull, burning, helps identify causes R: radiating/region; where it’s located, is it radiating, S: severity; how severe it is 1-10, numeric scaled, visual analogue scales, improving/disimproving, T: time; what were they doing at the time, time since last pain, how long pain lasts, associated symptoms

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7
Q

Medication adherence discuss

A

extent to which patients take their meds. Essential for achieving optimal therapeutic outcomes in many chronic conditions like HIV, DM, hypertension

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8
Q

Importance of highlighting drug errors

A

Essential aspect of medication management and patient safety. Identifies system failures, implement preventative measures to reduce risk of similar errors occurring again. Duty to report medication errors accurately and promptly.

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9
Q

Importance of highlighting errors under code of conduct 2014

A

Responsibility for quality of care including management of medications. Importance of continuous learning and improvements.

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10
Q

Importance of highlighting errors under scope of practice 2014

A

Professional responsibilities include need to report med errors promptly and accurately. Including cause of error, in medical record and to appropriate person.

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11
Q

Importance of highlighting errors under guidelines to medication management 2020

A

reporting both near misses and errors, regardless of if they caused harm. Non-punitive culture

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12
Q

Learning opportunities for highlighting errors

A

Continuously learn and improve, strategies for preventing future errors. 1) Continuing professional development and need to maintain up to date info, knowledge and skills by attending workshops and educational programmes. Professional development including clinical supervision, mentoring and reflective practice. Medication safety committees or working groups, med safety training and using incident reporting forms

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13
Q

Factors effecting medication adherence

A

Patient: poor knowledge or illness/med, administering and dosage of drugs, independent pausing and stopping, lack of competence in self management, hiding drug info, fear towards drugs, media source of info, lifestyle changes, poor control no symptoms, replacing prescription with self administered drugs
GP: reviewing full med info challenging and time consuming, accurate knowledge of home meds difficult to attain, too authorative for doctors, no teaching skills
Drug therapies: complex meds, polypharmacy, duration of meds/ withholding, ADR
Healthcare system: shortage of GP appointments, poor access, meds list not up to date, poor IT and communication

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14
Q

Advice for better med adherence

A

Patient: focus on health outcomes of self-management and therapies, support to understand, pharmacists as coaches for drug therapies, medication counselling, peer groups
GP: interprofessional practices to update drug lists, continuity of care and patient relationships
Drug therapies: interprofessional interventions, medication reconciliation, combination of products to reduce number of meds, checking and teaching medication devices
HC: interprofessional practices and interventions, HC shared patient info and better IT

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15
Q

Discuss storage and admin of schedule 2 drugs

A

Double locked press, keys with nurse in charge, checked daily, environment, controlled drug register kept for 2 years, different page for each class, signed by person giving and checking drugs, counter signed.

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16
Q

Process of admin IM injections

A

Prep: clean area, assemble equipment, sterile single use needles and syringes, reconstitution solution, alcohol swab, sharps container, hand hygiene, single use ppe, skin prep.
Needle: SC 25/26 G, IM 21/23 G
Vial/ ampoule
Deltoid, dorsogluteal, ventrogluteal, vastus lateralis- away from large blood vessels, nerves, bone
Procedure: infection control, medication checks 10R’s, identity and consent, cover ampoule when opening avoid injury, inspect solution- cloudiness, prep injection before going to patient, aspirate ampoule to expel air, 2 needle approach, dispose in sharps, select and locate site, positioned correctly, 90 degrees stretching skin, 1ml/10 seconds

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17
Q

Discuss interventions to reduce admin errors

A

Training and education - develop knowledge and skills for safe admin, recognize potential errors, occurs in variety of settings, implement best practices and stay up to date, automated delivery system such as automated dispensing cabinets reduce errors as correct med, person, time, dose also reduce risk of illegible handwriting of med, dose, interactions. Barcode med admin prevents errors, scan wristband to barcode, verifies patient identity, med, dose, route

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18
Q

describe nurses role in assessment and mgmt of pain post-surgery

A

critical to ensuring comfort and recovery, assess pain frequently - assessment tool, before and after meds and frequently, educating patient- re pain mgmt, importance of reporting pain, pain relief available and side effects, admin pain med- ADR, resp depression, sedation, nausea, nonpharma techniques, monitoring and documenting- pain and intervention and response, collab w HC team

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19
Q

Discuss nurse’s role in med concordance

A

Assess patients understanding of med regime, name, purpose, how to take, when to take, side effects. Provide education and support- importance of med concordance, how to manage side effects, provide resources. Encourage patient involvement, report concerns/ issues

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20
Q

Two strategies to improve med concordance

A

motivational interviewing, explore and resolve ambivalence about meds, barriers to adherence etc. , medication reconcilliation, comparing patients med regime at admission, transfer and discharge, ensure accurate and up to date and identify potential issues

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21
Q

Monitoring and documentation importance in med mgmt including assessing, planning, implementing and evaluating, communicating- discuss

A

Ensures safe and effective med mgmt, communication ensures appropriate info is shared among HC team and patients.
Assessing- communicate effectively with patient to assess medical Hx, current meds, allergies, ADR, communicate w MDT ensure med regime is appropriate and safe.
Planning- communication necessary to develop med plan tailored to patients needs, ensure they understand regime, how to take, when to take, side effects.
Implementing- ensure meds admin correctly, communicate w patients to ensure they understand
Evaluating- w patients ensure response if effective or any ADR
Documenting- accurate and complete records maintained

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22
Q

Affinity - drug-receptor actions

A

Attractive forces between the drug and receptor, causes drug to bind to receptor

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23
Q

Efficacy- drug-receptor actions

A

ability of drug when bound to initiate change, determines what happens once drug is bound, extent of which the drug can produce a response when all available receptors or binding sites are occupied, max effect drug can have regardless of dose

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24
Q

Potency

A

Amount of drug necessary to have an effect, measure of the concentration of a drug at which it is effective, determined by affinity of a drug for receptor and no. of receptors available

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25
Q

Specificity

A

Ability of receptor to recognise specific chemical configurations, lower potency and specificity, greater chance of side effects

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26
Q

Enzyme induction

A

increase in enzyme activity caused by a foreign compound, requires repeated exposure to compound and important role in drug interactions , consequences: accelerated clearance, reduced action, increased formation of toxic metabolites

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27
Q

Enzyme inhibition

A

decrease in enzyme activity caused by a foreign compound, requires only a single dose , consequences: impaired clearance, prolonged action

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28
Q

Clinical implications of enzyme induction

A

increased drug metabolism and elimination leading to reduced drug efficacy and toxicity, reduced plasma concentration of drugs leading to potential treatment failure, increased risk of drug interactions due to altered metabolism or other drugs

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29
Q

Clinical implications of enzyme inhibition

A

decreases rate of metabolism, increasing systemic exposure of a substrate drug, increasing propensity for side effects and potential toxicity, drug interactions due to changes in metabolism in other drugs, reduced metabolism and elimination of toxic substances increasing toxicity, changes in drug efficacy due to altered drug metabolism and elimination

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30
Q

Principal drugs in anaphylaxis treatment and description

A

Epinephrine- first line drug, constricts blood vessels, increases HR, relaxes airways which counteract severe allergic reaction, injection into thigh muscle
Antihistamines- block effects of histamine, a chemical released during rxn causing itching, swelling, e.g. cetirizine
Corticosteroids- reduce inflammation and swelling, conjunction w other meds above, prevent reoccurrence of anaphylaxis, e.g. prednisone
Bronchodilators- relax airways, easier to breath, relieve resp symptoms SOB, wheezing, e.g. albuterol
Vasopressors- increase BP and HR, counteract drop in BP, e.g. dopamine

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31
Q

What clinical situations should NSAID be avoided

A

history of peptic ulcers, GI bleed- irritate lining of stomach causing bleeding/ ulcers
CVD- increase risk of MI or stroke esp w hypertension/ high cholsterol
Chronic kidney disease - impair kidney function and worsen disease
Allergy or hypersensitivity- develop allergic rxn’s
Bleeding disorders- increase risk of bleeding if on anticoag

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32
Q

Why are elderly more susceptible to drug reactions

A

Age- body composition, higher fat lower muscle, affects distribution of drug and elimination from body, higher drug conc. and increased risk of toxicity
Organ function- declining, esp liver and kidneys, affects drug metabolism and elimination, higher drug conc. and toxicity
Polypharmacy- multiple meds, increase risk of drug interactions and ADR, difficult to identify cause of ADR
Medical conditions- multiple chronic conditions more likely, affects metabolism , absorptions, elimination and distribution of drugs, increase drug interaction and ADR
Cognitive and physical impairments- affect ability to adhere to meds or report symptoms, hard to manage and identify
Reduced physiological reserve- less ability to compensate for effects of drugs or other stressors, increase risk of ADR

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33
Q

Principal drugs used in treatment of hypertension

A

Younger than 55 A, older/black- D or D
A+C/D
A+C+D
further diuretic therapy or BB

ACEI- angiotensin converting enzyme inhibitor, inhibit ACE reduce total peripheral resistance and stroke volume
ARB- angiotensin receptor blockers, reduce TPR and SR
Beta blockers- reduce HR and SV
CCB- calcium channel blockers, reduce TPR
Diuretics- reduce SR

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34
Q

ACEI

A

Block formation of Angiotensin II, inhibit aldosterone release, reduce BP, block breakdown of bradykinin, reduce proteinurea in diabetics e.g. Catopril
Side effects-
Cough- bradykinin and substance P
Angioedema
Proteinuria
Taste changes
Pregnancy
Rash
Increased renin and lower angiotensin II
Lytes- hyperkalemia, decreased aldosterone secretion

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35
Q

ARB

A

Block angiotensin II receptors, bind to angiotensin receptor and block vasoconstriction e.g. losartan
Side effects- fatigue, hyperkalemia, renal failure, syncope

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36
Q

Beta blockers

A

Reduce force of contraction, block beta receptors e.g. metoprolol
Side effects- bradycardia, conduction, heart failure, bronchospasm, vasoconstriction
Contraindications- asthma, bradycardia, cardiac failure, diabetes

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37
Q

CCB

A

Block calcium channels, reduce calcium available to contractile proteins, reduce cardiac contractility, vascular smooth muscle tone and BP e.g. nicardipine
Side effects- headache, oedema, flushing

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38
Q

Diuretics

A

Facilitate diuresis - Thiazides, loop diuretics, potassium-sparing diuretics e.g. furosemide
Side effects- ototoxic, hypocalcemia, hypovolemia, blood disorders

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39
Q

Advice for hypertensive patient

A

Smoking cessation, activity 30-60 mins/ day, restrict alcohol intake, restrict salt <6/day, weight reduction, caffeine intake, relaxation therapies

40
Q

Thiazides

A

Inhibit sodium transport in distal tube, vasodilator effect, e.g. hydrochlorothiazide
Indications- heart failure, hypertension, pulmonary oedema, cirrhosis
Side effects- hypercalcemia, glycaemia, uricemia, hypochloremia, kalemia, magnesemia, natremia

41
Q

Loop diuretics

A

Inhibit sodium and potassium transport in the loop e.g. furosemide
Indications- heart failure, hypertension
Side effects- ototoxic, hypercalcemia, hypovolemia, blood disorders

42
Q

Potassium sparing diuretics

A

MRA- mineralocorticoid receptor antagonists, e.g. spironolactone
Acts on distal tube of kidneys, increase excretion of sodium, water chloride, calcium, decrease secretion of potassium and hydrogen ions
Indications- hypertension, hypokalemia
Side effects- dizziness, orthostatic hypotension, dry mouth, nausea, vomiting, diarrhea

43
Q

Principal side effects of penicillin

A

Allergic reactions- 10% patients, rash, itching to anaphylaxis or angioedema
GI- N&V, diarrhea, abdo pain
Skin rash- non-allergic rash, or more severe stevens-johnson sydrome
Muscle spasms, tachycardia, tachypnea, fever, chills, flushing, hypotension

44
Q

Side effects of short term alcohol abuse

A

Slurred speech, drowsiness, vomiting, diarrhea, gi discomfort, headaches, blurred vision, distorted hearing, reduced perception and coordination, unconsciousness

45
Q

Side effects of long term alcohol abuse

A

alcohol poisoning, liver damage, injuries, social problems, hypertension, CVD, stroke, gastritis, ulcers, cancers, withdrawal seizures, tachycardia, ataxia, dependency, depression, cardiomyopathy, pancreatitis

46
Q

differences between agonists and antagonists with reference to drug and receptor interactions

A

Agonists- bind to receptors, cause conformational change, result in a response, A+R -> AR -> AR*, occupy receptors and activate them

Antagonists- bind to receptors, don’t cause necessary conformational change, don’t cause activation, have no efficacy, prevent agonists from binding or block their action

47
Q

First pass metabolism

A

Drug given orally, metabolized at a specific location in body that results in a reduced concentration of the active drug upon reaching its site of action or systemic circulation, GI or hepatic metabolism

48
Q

Side effects of benzodiapine use

A

over dose- ataxia, altered mental status, coma, hypotonia, hypotension, resp depression, nystagmus, withdrawals - palpitations, anxiety, insomnia, stiffness, delusions

49
Q

Side effects of smoking

A

Increase HR, BP, bronchospasms, bronchitis, diarrhea, ulcers, tremor, skin, eyes

50
Q

Principal drugs in treatment of constipation

A

Bulk forming laxatives, stimulant laxatives, osmotic laxatives, stool softeners, lubricant laxatives

51
Q

Bulk forming laxatives

A

Isphaghula husk- natural or synthetic fibers that absorbs water and promotes bowel movements. stimulates peristalsis and adds bulk to stool

52
Q

Stimulant laxatives

A

Bisacodyl (dolcolax)- Stimulate the muscles of the intestines, promote bowel movement, increase fluid secretion and altering electrolyte balance in intestines, stimulating peristalsis

53
Q

Osmotic laxatives

A

Magnesium hydroxide/ lactulose- drawing water into intestines, softens stool and promotes bowel movement

54
Q

Stool softeners

A

Mineral Oil
Softening the stool, easier to pass, decrease surface tension of stool and allows water and lipids to penetrate stool and intestinal walls

55
Q

Principal effects of opioid drugs

A

Constipation- slows down movement of intestines, common and severe
Nausea and vomiting- high doses/ extended period
Sedation- drowsiness, lethargy, impaired cognitive ability
Resp depression- slow breathing rate, high doses/ resp problems
Itching- antihistamines, usually mild
Hormonal effects- release cortisol and testosterone, decreased libido, fertility and immune function
Dependence and addiction- physical dependence, withdrawal if stopped

56
Q

Side effects of loop diuretics

A

Ototoxic, hypocalcemia, hypovolemia , blood disorders, hypokalemia, hypochloremia

57
Q

Principal drugs used in asthma

A

Bronchodilators (relief)- relax muscles in lungs and widen airways - beta2 agonists, antimuscarinics, methylxanthines

Anti- inflammatory (controllers)- decrease airway sensitivity and reduce production of mucous,- corticosteroids, leukotriene receptor antagonists, chromones

Novel therapy- monoclonal antibodies against IgE

58
Q

B2 agonists SABA

A

Salbutamol, bronchodilator
Side effects- headache, hypokalemia, tachycardia, long qtc

59
Q

B2 agonists LABA

A

Formoterol, taken with corticosteroids in combined inhaler, formoterol with budesonide

60
Q

Corticosteroids

A

Anti-inflammatory
Inhaled - budesonide
Oral - prenisoline

61
Q

Leukotriene receptor antagonists

A

Anti-inflammatory
Montelukast
Block leukotriene receptors, reduce septum eosinophilia
Add on therapy

62
Q

Xanthines

A

Theophylline
Phosphodiesterase inhibition, adenosine antagonism, catecholamine release, immune mediator inhibition

63
Q

Pharmacokinetics

A

How the body reacts on the drug/ fate of drug on the body, including absorption, distribution, metabolism and excretion of drug. Drug movement throughout body

64
Q

Pharmacodynamics

A

Effects of the drug on the body, what drug does to HR, BP, RR, symptoms/ disease improve/disimprove

65
Q

Absorption of drug

A

Oral, principal site of absorption is SI, for drug effects it must; reach target site, in adequate concentration, active form, interact w target

66
Q

Distribution of drug

A

Simple- without energy expenditure, down conc. gradient, lipid molecules diffuse well, acids and bases don’t.
Facilitated- uses protein to facilitate movement of molecules across membrane
Active- cell transports substance against its conc. gradient, cell expends energy, uses ATM e.g. sodium potassium pump

67
Q

Patients to know about their medication

A

name and purpose, what its treating and how it works, dosage and frequency, when/how, side effects- mild-severe, interactions w other medications, storage/ disposal, appointments, contact info

68
Q

Principal drug in peptic ulcer disease

A

Proton pump inhibitors
Histamine H2 receptor antagonists
Antacids
Antibiotics
Cytoprotective agents

69
Q

PPI

A

Omeprazole
reduce production of stomach acid by blocking the enzyme responsible for acid secretion in stomach, reduces acidity of stomach and allows ulcers to heal

70
Q

Histamine H2 receptor antagonists

A

Cimetidine
block the histamine H2 receptors in stomach, reduces production of acid

71
Q

Antacids

A

Aluminium hydroxide
Neutralize stomach acid, directly reacts with acid in the stomach, rapid relief but doesn’t treat cause

72
Q

Antibiotics

A

Amoxocillin
Treat PUD caused by H.Pylori, kill bacteria that cause infection, ulcers heal

73
Q

Cytoprotective agents

A

Sucralafate
protect lining of stomach from acid damage and promote healing of ulcers

74
Q

Novel anticoag

A

Apixaban, dabigatran, edoxaban, rivaroxaban

75
Q

Apixaban

A

Inhibits free and clot bound FXa and prothrombinase activity which inhibits clot growth
Bleeding gums, nose bleeds, red/brown urine, lethargy, rash

76
Q

Dabigatran

A

Reversibly binds to the active site on the thrombin molecule, preventing thrombin mediated activation coag factors
Bleeding, GI discomfortm SOB, palpitations, dizzy

77
Q

Edoxaban

A

Direct, reversible, inhibition of factor Xa
Indigestion, dizzy

78
Q

Rivaroxaban

A

Competitively inhibits free and clot bound Xa
Bleeding, tiredness, SOB, rash, nausea

79
Q

Heparins

A

Binds to antithrombin 3, catalyses the Xa, IXa and XIIa, thrombin most senstive, reversal with protamine
Alopecia, hyperkalemia, haemmorhage

80
Q

Oral anticoag

A

Warfarin : Vit K antagonist, interferes with cyclical ocnverson of vit K, reducing clotting factors 2,7,10 and anticoag proteins C and S, reverse with prothrombin complex concentrate, teratogen

81
Q

Principal actions of NSAID

A

Pain relief- mild to moderate pain, headaches, menstrual cramps, joint pain
Reduction of inflammation- arthiritis, tendonitis, bursitis
Reduction of fever- lowering body’s temperature set point in the brain

82
Q

Side effects of NSAID

A

GI- irritate lining of stomach and intestines, stomach pain, nausea, ulcers, bleeding, perforation of stomach
Kidney damage- impair kidney function esp in patients with existing kidney disease/ dehydration
CVD- increase risk of heart attack and stroke
Allergic reaction- hives, rash, SOB, aspirin sensitivity at risk
Dizziness, headaches, ringing in ears, fluid retention

83
Q

Principal types of oral hypoglycemics in treatment of DM

A

Biguanides- metformin
Sulfonylureas- glipizide
Glinides- repaglinide
glitazones - resoiglitazone
alpha-glucosidase - acarbose
AGLT-2 inhibitors- canagliflozin

84
Q

Differences between agonists and partial agonists

A

Agonists- bind to receptors, cause conformational change, result in a response
Partial agonist- bind to receptor but don’t cause full response, low efficacy, must occupy large no. of receptors to have a response, occupy receptors that could be occupied by full agonists therefore act as antagonists , difficult to reverse, greater receptor occupancy

85
Q

List methods of administrating drugs

A

Enteral - NG, gastrosotomy, Oral , sublingual, buccal
Topical- skin, ears, eyes, nose, inhalation, rectum ,vagina
Parenteral- IV, IM , SC, ID

86
Q

Oral admin of drugs

A

75% absorbed in 1-3 hrs affected by- GI motility, visceral blood flow- after meals slower absorption, drug size and coating, chemical properties
Problems- accuracy, compliance, acid destroy drug, abnormal flora, interactions w other drugs, motility of bowel, first pass metabolism

87
Q

Bioavailability

A

Fraction of the drug administered that reaches systemic circulation

88
Q

Where do drugs go

A

Systemic circulation, blood brain barrier, fat, tissues

89
Q

Half life meaning

A

the time taken for the amount of a drug’s active substance in your body to reduce by half, determines the duration of drug action

90
Q

Infants and children risk of taking medication

A

Absorption- reduced gastric acidity, percutaneous absorption of drug as stratum corneum is thin
Distribution- plasma protein levels low and drugs which bind plasma proteins displace bilirubin, increased permeability of blood brain barrier, higher percentage of body weight is water
Metabolism- immature enzyme system
Excretion - reduced effectiveness

91
Q

Why are elderly at risk of taking medication

A

Cognitive ability- 5W’s
Absorption- dysphagia, motility, decreased blood flow
Distribution- increase in body fat, decrease in albumin
Metabolism- less effecient
Excretion- decreased GFR and tubular function, renal impairment
Increased sensitivity to a variety of drugs

92
Q

Why are patients with CVD at risk of taking medication

A

Absorption- delayed
Distribution- reduced volume of distribution, plasma conc. higher, importance with narrow therapeutic ratio drugs
Metabolism- reduced clearance, increase steady state conc of drugs undergoing phase I metabolism
Excretion- reduced blood flow, reduced clearance, increased steady steady of drugs excreted mainly by kidney

93
Q

Why are patients with resp disease at risk of taking medication

A

Effects of ventilation, diffusion abnormalities

94
Q

List main drug groups in treatment of MI

A

Thienopyridines- antiplatelet, heparin, RAS-ACEI renin angiotensin system angiotensin converting enzyme inhibitor, Oxygen, Morphine, B blocker, invasive, Nitrates, Statin, ASA- acetylsalicylic acid

95
Q

Discuss antiplatelet drugs

A

Inhibit glycoprotein IIb/ IIIa receptors on platelets, Ischemic heart disease, stroke, Nitrates- glycerol trinitrates; releaxtion of smooth muscle of veins and arterioles, reduction in venous return which reduces left ventricular work load, arterioles relax
Aspirin- acute coronary syndrome, primary and secondary intervention of CVD; inhibits cyclooxygenase, preventing formation of thromboxane A2
P2Y12 inhibitors- inhibits P2Y12 ADP receptor, preventing platelet activation