NTs 1 b Flashcards
NA: released from? also a?
released from sympathetic post ganglionic nerve endings. also a CNS NT.
NA: diffuse projections from where to where
from locus coeruleus to all brain regions
synthesis of NA: name all the molecules
tyrosine to DOPA to dopamine to NA to A
structure of NA
phenyl ring with two OHs + CH (OH) + CH2 + NH2
what marks NA neurons
dopamine B-hydroxylase
what marks all catecholamine neurons
tyrosine hydroxylase
synthesis of NA: what happens to tyrosine?
tyrosine transporter via Na+ dependent carrier. converted to DOPA by tyrosine hydroxylase = RLS.
synthesis of NA: after DOPA to end
converted to dopamine by DOPA decarboxylase. then goes into vesicle, converted to NA by dopamine b hydroxylase. in adrenal gland, made into adrenaline via phenylethanolamine n methyl transferase
inactivation of NA: 3 steps
uptake via cocaine sensitive transporter. metabolism by MAO in nerves, or by COMT in liver
NA: nerve terminal inactivation: where and what enzyme to what product
mitochondria, by MAO = aldehyde.
aldehyde: what two options and what metabolites (maj or minor)
aldehyde + dehydrogenase = organic acid, major. aldehyde reductase = alcohol, minor.
circulating CA: taken up into what organ, then metabolized how
liver by uptake 2: then COMT (then MAO and same steps)
detection of CAs via what technique?
amperometry: oxidation of CAs associated with generation of H ions + e. electrons detected by carbon fiber
ATP is found in what nerves? important for what areas?
NANC nerves. bladder + GI tract.
ATP released with? roles?
released with NA from sympathetic nerves. CNS NT, role in pain transmission esp chronic and neuropathic, released from damaged cells
