💊NT Termination Flashcards
1
Q
AchE
A
breaks down Ach ↑ cholinergic transmission
↑ para
↑ NMJ actions - muscle twitches –> paralysis
2
Q
Short acting Edrophonium
A
diagnostic, improves myasthenia gravis
3
Q
Medium acting Neostigmine
A
reverse neuromuscular block + atonic states of GI /bladder after surgery
4
Q
Long acting Organophosphorus insecticides, VX agent (Kim Jong Nam), Sarin
A
Irreversible, need new AchE synthesis, ∴dangerous
5
Q
Reuptake inhibitors
A
NA terminated by reuptake then 𝔼 breakdown in terminal
6
Q
Cocaine / tricyclic anti-depressants (imipramine)
A
❌uptake transporter
Potentiate adrenergic transmission
↑sympathetic
7
Q
MAO inhibitor eg Moclobemide
A
Prevent NA breakdown, potentiate NA in brain
☹
8
Q
SSRIs
A
☹– ↓ 5-HT levels in brain
eg Fluoxetine, prevent 5-HT reupatake
↑ 5-HT in synapse∴↑ neurotransmission
