💊 ↑ Dopamine

Question 1

DOPA & MAO/COMT inhibitors

Answer 1

L-tyrosine ——(tyrosine hydroxylase)——-> DOPA—–DDC—–> Dopamine- breakdown by MAO/COMT

Question 2

Levodopa

Answer 2

Prescribed w peripheral DDC inhibitor Carbidopa (doesn’t cross BBB)
Prevent DOPA–>Dopamine in periphery
Diminishes periphery effects
↑ DA synthesis in brain

Also prescribed w
COMT inhibitor entacapone

and/or

MAO-B inhibitor Selegiline
↓ dopamine metabolism∴ ↑dopamine