💊 AP Propagation

Question 1

Local anaesthetics Lignocaine

Answer 1

Prevent AP conduction & transmission in sensory nerves – stops inputs to brain that code for pain

Question 2

Anti-epileptic Phenytoin

Answer 2

Prevent ⇧ transmission during high ƒ firing in CNS -seizures

Question 3

Analgesics Ziconotide

Answer 3

Synthetic form of ω-conotoxin (marine cone snail toxin)
potent blocker of vgCa
100-1000x > than morphine
Prevents synaptic release of transmitters that conduct pain signals

Also GABApentin- neuropathic pain