NSAIDs, Opioids

Question 1

What drug is used in addiction clinics

Answer 1

Methadone

Question 2

Which of the COX enzymes do we want to inhibit in NSAIDS

Answer 2

Cox 2 - mayjor source of prostaglandins in inflammed tissue

Question 3

What COX enzyme do antiplatelet drugs aim to inhibit

Answer 3

COX1 - thromboxane formation

Question 4

Acetylsalicylic acid is also known as:

Answer 4

Aspirin

Question 5

why is aspirin as an antiplatelet in a low dose

Answer 5

In a low dose it only inhibit cox 1. we don’t want to inhibit cox 2 as its involved in prostacyclin formation which inhibits thrombus formation.

Question 6

Propionic acids AKA:

Answer 6

Ibuprofin

Question 7

Acetic acid aka

Answer 7

Diclofenac

Question 8

Is paracetamol antiinflammatory?

Answer 8

No. Only analgesic and antipyretic effects.

Question 9

Peak plasma concentration for paracetamol occurs how long after taking :

Answer 9

30-60 mins

Question 10

Patients whom NSAIDs should be used with caution:

Answer 10

• Asthma (increased risk of bronchospasm)
• Coagulation defects (increased bleeding risk)
• Hepatic and renal impairment
• Elderly
• Pregnancy
• Combination therapy (not w other nsaids)

Question 11

Most common adverse effects from NSAIDs:

Answer 11

• GI
• Renal
• Headaches

Question 12

Where do opioids work as opposed to NSAIDs (CNS or periphery)

Answer 12

CNS.

Nsaids - periphery.

Question 13

Why are Opioids, NSAIds and paracetamol often prescribed in combination therapy

Answer 13

1. Increase efficacy
2. Reduce adverse side effects
3. Delay tolerance

Question 15

Typical ibuprofen dose:

Answer 15

200-400mg every 4-6 hours, (max 6 tablets in 24 hours)

Question 16

Typical paracetamol dose

Answer 16

500-1000mg every 4-6 hours, maximum of 8 tablets in 24 hours

Question 17

SSRIs and TCAs should not be used with:

Answer 17

alcohol

Question 18

SSRIs should not be used with NSAIDs

True or false

Answer 18

True