NSAIDs Non Selective Cox Inhibitor

Question 1

Salicylic acid derivatives…

Answer 1

✓Aspirin
✓Aloxiprine
Aminosalicylic acid
✓Disflunisal

Question 2

✓Most widely used NSAIDs
✓Less gastric irritant than other NSAIDs
✓More nephrotoxic
✓Often combined with PGE analogue to decrease gastric ulceration
✓Topical gel is available

Answer 2

Declofenac

Question 3

Have minimal effect on platelet aggregation

Answer 3

Sulindac and ketorolac

Question 4

Prodrug and has long t 1/2

Answer 4

Sulindac

Question 5

Potent analgesic but it can cause severe GIT bleeding

Answer 5

Ketorolac

Question 6

No reported interactions with oral anticoagulants

Answer 6

Ibuprofen, fenoprofen, ketoprofen

Question 7

✓Good alternative to aspirin in children with flu fevers
✓ long term using it associated with an increased incidence of hypertension in women

Answer 7

Ibuprofen

Question 8

Induce nephrotic syndrome

Answer 8

Fenoprofen

Question 9

Very potent COX inhibitor but more toxic
Approved to speed the closure of patent ductus arteriosus in premature children by inhibiting production of PGs

Answer 9

Indomethacin

Question 10

Long (t1/2)about (45 hours)
Bleeding and ulceration are more likely with ….than the other NSAIDs

Answer 10

Perioxicam

Question 11

Decrease PGE2 synthesis in hypothalamus

Answer 11

Aspirin

Question 12

Decrease response to interleukin-1

Answer 12

Aspirin

Question 13

Cutaneous VD and increase sweating

Answer 13

Aspirin