Analgesic Antipyretic

Question 1

Is from analgesic antipyretic

Answer 1

Acetaminophen ( paracetamol)

Question 2

Completely and rapid absorbed from GIT with peak after 30 min

Answer 2

Paracetamol (acetaminophen)

Question 3

Metabolized by conjugation in liver
At high doses it is converted into toxic metabolite (N Acetyl- benzoquinone) that is responsible for hepatotoxicity

Answer 3

Paracetamol

Question 4

Excreted mainly renal

Answer 4

Paracetamol

Question 5

✓ Selective COX III inhibitor
✓ No anti-inflammatory action bec it has no effect on the enzymes that synthesise PGs

Answer 5

Paracetamol (acetaminophen)

Question 6

✓ Used as analgesic and antipyretic when aspirin is contraindicated
Ex ( patients with peptic ulcers, hemophilia)
✓ Administrated in pregnancy with greater safety than aspirin

Answer 6

Paracetamol

Question 7

Paracetamol can cause

Answer 7

1- skin rush and drug fever as allergic reactions
2- long term use may lead to renal failure