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BBDA > NSAIDs/DMARDS > Flashcards

NSAIDs/DMARDS Flashcards

1
Q

Toradol

A

Ketorolac

NSAID

used for moderate post-surgical pain up to 5 days

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2
Q

Motrin

A

Ibuprofen

NSAID

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3
Q

Aleve/Naprosyn

A

Naproxen

NSAID

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4
Q

Orudis

A

Ketoprofen

NSAID

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5
Q

Indocin

A

Indomethacin

NSAID

used for gout

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6
Q

Feldene

A

Piroxicam

NSAID

long half-life, high risk for GI ulcers

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7
Q

Clinoril

A

Sulindac

NSAID

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8
Q

Lodine

A

Etodolac

NSAID

COX-2 selective

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9
Q

Mobic

A

Meloxicam

NSAID

COX-2 selective

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10
Q

Relafen

A

Nabumetone

NSAID - COX-2 selective

Prodrug, long half-life

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11
Q

Voltaren

A

Diclofenac

NSAID

COX-2 selective

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12
Q

Celebrex

A

Celecoxib

NSAID - COX-2 selective

CV risk

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13
Q

Nalfon

A

Fenoprofen

NSAID

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14
Q

Ansaid

A

Flurbiprofen

NSAID

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15
Q

Daypro

A

Oxaprozin

NSAID

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16
Q

Rheumatrex

A

Methotrexate

DMARD

inhibits proliferation and stimulates apoptosis of immune-inflammatory cells
Folic acid antagonist - don’t take folic acid on same day as Methotrexate

ADR - N/V/D, leukopenia, teratogenic, thrombocytopenia,

17
Q

Plaquenil

A

Hydroxychloroquine

DMARD

inhibits t-lymphocyte responses, leukocyte chemotaxis, DNA/RNA synthesis
stabilization of lysosomal enzymes
trapping of free radicals

ADR - N/V/D, rash, ocular toxicity, alopecia (spot balding)

18
Q

Azulfidine

A

Sulfasalazine

DMARD

suppresses t-cell response
inhibits b-cell proliferation, cytokine release

ADR - N/V/D, rash, leukopenia, alopecia, elevated liver enzymes

19
Q

Arava

A

Leflunomide

DMARD

suppresses t-cell response
inhibits b-cell proliferation, cytokine release

ADR - Diarrhea, alopecia, leukopenia, thrombocytopenia, teratogenic

20
Q

Enbrel

A

Etanercept

DMARD biologic - TNF-alpha inhibitor

inhibits TNF-alpha function

Uses:
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriatic Arthritis
Crohn's Disease

ADR - injection site reactions, lupus-like syndrome, increased risk of infection/malignancy, HF exacerbation, neurologic demyelinating syndromes

21
Q

Humira

A

Adalimumab

DMARD biologic - TNF-alpha inhibitor

inhibits TNF-alpha function

Uses:
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriatic Arthritis
Crohn's Disease

ADR - injection site reactions, lupus-like syndrome, increased risk of infection/malignancy, HF exacerbation, neurologic demyelinating syndromes

22
Q

Remicade/Inflectra

A

Infliximab

DMARD biologic - TNF-alpha inhibitor

inhibits TNF-alpha function

Uses:
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriatic Arthritis
Crohn's Disease

ADR - injection site reactions, lupus-like syndrome, increased risk of infection/malignancy, HF exacerbation, neurologic demyelinating syndromes

23
Q

Colcrys

A

Colchicine

inhibits leukocyte migration and phagocytosis

ADR - N/V/D, abdominal pain

24
Q

Benuryl

A

Probenecid

Uricosuric agent

organic acids that inhibit reabsorption of uric acid in proximal tubule

ADR - Gi upset, rash, renal stones

25
Q

Zyloprim

A

Allopurinol

Inhibits xanthine oxidase, preventing the conversion of hyoxanthine and xanthine to uric acid

ADR - gout flare, N/V/D, headache, hypersensitivity and skin rash

26
Q

Uloric

A

Febuxostat

Inhibits xanthine oxidase, preventing the conversion of hyoxanthine and xanthine to uric acid

ADR - gout flare, N/V/D, headache, LFT elevations

27
Q

Krystexxa

A

Pegloticase - IV ONLY

urate-oxidase enzyme which converts uric acid to allantoin
DOESN’T INHIBIT FORMATION OF URIC ACID

ADR - infusion reactions, gout flares, nephrolithiasis, muscle spasms, arthralgia

BBDA (6 decks)

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