Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BBDA > Antipsychotics/Antidepressants/Antiseizure > Flashcards

Antipsychotics/Antidepressants/Antiseizure Flashcards

1
Q

Celexa

A

Citalopram

SSRI

MOA - block the reuptake of serotonin back into the presynaptic neuron

ADR - hypokalemia, hypomagnesemia, bradycardia, QTc elongation can lead to Torsades de pointe, risk of GI bleeding, sexual dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Lexapro

A

Escitalopram

SSRI

MOA - block the reuptake of serotonin back into the presynaptic neuron

ADR - diarrhea, nausea, QTc prolongation (less), risk of GI bleeding, sexual dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Prozac

A

Fluoxetine

SSRI

MOA - block the reuptake of serotonin back into the presynaptic neuron

ADR - most activating/insomnia, hypoglycemia, very long half-life, risk of GI bleeding, sexual dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Zoloft

A

Sertraline

SSRI

MOA - block the reuptake of serotonin back into the presynaptic neuron

ADR - Activating/insomnia, hypoglycemia, WORST GI PROBLEMS (nausea, diarrhea, vomiting), risk of GI bleeding, sexual dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Paxil

A

Paroxetine

SSRI

MOA - block the reuptake of serotonin back into the presynaptic neuron

ADR - MOST SEDATING, MOST ANTI-ACH EFFECTS (SPSS), sexual dysfunction, risk of GI bleeding, QTc prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cymbalta

A

Duloxetine

SNRI

MOA - block the reuptake of serotonin and norepinephrine back into the presynaptic neuron

ADR - activation, nausea, headache (take at night), dry mouth, sexual dysfunction, avoid in hepatic dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Effexor

A

Venlafaxine

SNRI

MOA - block the reuptake of serotonin and norepinephrine back into the presynaptic neuron

ADR - hypertension, headache (take at night), nausea, activation, dizziness, sexual dysfunction, dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pristiq

A

Desvenlafaxine

SNRI

MOA - block the reuptake of serotonin and norepinephrine back into the presynaptic neuron

ADR - nausea, headache (take at night), dry mouth, dizziness, activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Elavil

A

Amitriptyline

TCA - the “original” SNRI

MOA - block the reuptake of serotonin and norepinephrine back into the presynaptic neuron

ADR - anti-ACh (SPSS), sedation, sexual dysfunction, weight gain, seizures, QTc prolongation, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Sinequan

A

Doxepin

TCA - the “original” SNRI

MOA - block the reuptake of serotonin and norepinephrine back into the presynaptic neuron

ADR - anti-ACh (SPSS), sedation, sexual dysfunction, weight gain, seizures, QTc prolongation, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pamelol

A

Nortriptyline

TCA - the “original” SNRI

MOA - block the reuptake of serotonin and norepinephrine back into the presynaptic neuron

ADR - anti-ACh (SPSS), sedation, sexual dysfunction, weight gain, seizures, QTc prolongation, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Wellbutrin/Zyban

A

Bupropion

Antidepressant

MOA - norepinephrine-dopamine reuptake inhibitor

ADR - activation, headache (take at night), dry mouth, hypertension, risk of seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Remeron

A

Mirtazapine

Antidepressant

MOA - alpha2-adrenergic antagonist effects stimulate NE and serotonin release, potent antagonist of serotonin and histamine receptors

ADR - sedation, increased appetite, dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Abilify

A

Aripiprazole

2nd Generation Antipsychotic

MOA - Dopamine 2 partial agonist

ADR - activating/agitating, akathisia, dyslipidemia, elevation of fasting triglycerides, insulin resistance, FDA warning for impulse-control issues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Zyprexa

A

Olanzapine

2nd Generation Antipsychotic

MOA - combination of DA and serotonin type 2 receptor site antagonism

ADR - WEIGHT GAIN, GREATEST METABOLIC RISK, orthostatic hypotension, hypertriglyceridemia, hypercholesterolemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Seroquel

A

Quetiapine

2nd Generation Antipsychotic

MOA - antagonizes serotonin 5-HT1A and 5-HT2, dopamine D1 and D2, histamine H1, and adrenergic α1 and α2 receptors.

ADR - weight gain, SEDATION, dyslipidemia, insulin resistance, orthostatic hypotension, anti-ACh effects (SPSS)

17
Q

Risperdal

A

Risperidone

2nd Generation Antipsychotic

MOA - potent serotonin-5-HT2 antagonist with weaker dopamine-D2 antagonism. Whereas typical antipsychotics are dopamine antagonists, the additional serotonin antagonism increases efficacy for negative symptoms of schizophrenia and reduces the likelihood of extrapyramidal symptoms

ADR - sexual dysfunction, weight gain, dyslipidemia, sedation, hyperprolactinemia (breast enlargement/tenderness), amenorrhea (abnormal absence of menstruation)

18
Q

Eskalith/Lithobid

A

Lithium - TWF

Bipolar Disorder Agent/Mood stabilizer

MOA - not known but may work by: 1) inhibiting 2nd messenger enzymes 2) modulating G-proteins 3) interacting with various sites on downstream signal cascade

ADR - nausea (early on), dry mouth, polyuria, tremor, weight gain, hypothyroidism, acne, thinning hair, seizures, delirium, confusion

19
Q

Nardil

A

Phenelzine

MAO-I

MOA - inhibit monoamine oxide that breaks down monoamines (DA, NE, serotonin)

ADR - postural hypotension, anti-ACh, SEDATION, sexual dysfunction, hepatic issues, DRUG-DRUG INTERACTIONS (DM-cough suppressant, ALL ANTIDEPRESSANTS, methadone, tramadol, fentanyl, cocaine, amphetamine), DRUG-FOOD INTERACTIONS (cheese, chocolate, beer, wine, smoked meats, pickled or canned foods)

20
Q

Parnate

A

Tranylcypromine

MAO-I

MOA - inhibit monoamine oxide that breaks down monoamines (DA, NE, serotonin)

ADR - postural hypotension, anti-ACh, SEDATION, sexual dysfunction, hepatic issues, DRUG-DRUG INTERACTIONS (DM-cough suppressant, ALL ANTIDEPRESSANTS, methadone, tramadol, fentanyl, cocaine, amphetamine), DRUG-FOOD INTERACTIONS (cheese, chocolate, beer, wine, smoked meats, pickled or canned foods)

21
Q

Thorazine

A

Chlorpromazine

1st Generation Antipsychotic

MOA - DA2 receptor antagonist, depresses release of hypothalamic and hypophyseal hormones

ADR - akathisia, dystonia, tardive dyskinesia, sedation, anti-ACh effects (SPSS), weight gain, sexual dysfunction

22
Q

Haldol

A

Haloperidol

1st Generation Antipsychotic

MOA - DA 1 and 2 receptor antagonist, depresses release of hypothalamic and hypophyseal hormones

ADR - akathisia, dystonia, tardive dyskinesia, sedation, anti-ACh effects (SPSS), weight gain, sexual dysfunction

23
Q

Prolixin

A

Fluphenazine

1st Generation Antipsychotic

MOA - DA 1 and 2 receptor antagonist, depresses release of hypothalamic and hypophyseal hormones

ADR - akathisia, dystonia, tardive dyskinesia, sedation, anti-ACh effects (SPSS), weight gain, sexual dysfunction

24
Q

Clozaril

A

Clozapine

2nd Generation Antipsychotic

MOA - noradrenolytic, anti-ACh, anti-Histaminic and arousal reaction inhibiting effects are significant, affinity for DA4 receptor accounts for striking effects in control of behavioral and psychiatric symptoms with low incidence of EPS;—-; effective for reducing suicidality

ADR - metabolic side effects, severe sialorrhea (hyper salivation), dose related risk of seizures (>600mg/day), Absolute Neutrophil Count (ANC) every week CBC for first 6 months, every 2 weeks CBC for second 6 months, then monthly CBC thereafter

25
Q

Latuda

A

Lurasidone - administer with at least 350 calories

2nd Generation Antipsychotic

MOA - unknown, suggested: involve mediation of central DA type 2 and serotonin type 2 receptor antagonism

ADR - less sedation and akathisia if dosed at night, low risk of weight gain or dyslipidemia, no QTc prolongation,

26
Q

Geodon

A

Ziprasidone - given with at least 500 calories

2nd Generation Antipsychotic

MOA - moderately inhibits NE and serotonin reuptake

ADR - activation, QTc prolongation, lowest risk for weight gain, low risk for dyslipidemia and insulin resistance,

27
Q

Tegretol

A

Carbamazepine

Anticonvulsant - narrow spectrum (focal onset)

MOA - acts presynaptically to block firing of action potentials, which decreases the release of excitatory neurotransmitters, and postsynaptically by blocking high-frequency repetitive discharge initiated at cell bodies.

ADR - autoinduction (induces it’s own metabolism), GI upset, double vision, sedation (initial)

28
Q

ONFI

A

Clobazam

Anticonvulsant - like a benzodiazepine but you don’t build tolerance

MOA -

ADR - dizziness

29
Q

Depakote

A

Divalproex Sodium

Anticonvulsant - broad spectrum (focal and generalized)

MOA -

ADR - GI upset (TWF), sedation, tremor, weight gain, hair loss (temporary)

30
Q

Neurontin

A

Gabapentin

Anticonvulsant - narrow spectrum (focal seizures)

MOA - its mechanism of action is not known. Gabapentin does not interact with GABA receptors or alter the formation, release, degradation, or reuptake of GABA.

ADR - MCD

31
Q

Vimpat

A

Lacosamide

Anticonvulsant - may be broad spectrum

MOA - stabilizes hyperexcitable neuronal membranes and inhibits neuronal firing

ADR - headache, dizziness, diplopia, nausea

32
Q

Lamictal

A

Lamotrigine

Anticonvulsant - focal onset and generalized

MOA - inhibits voltage-dependent sodium channels, thereby stabilizing neuronal membranes and reducing the release of excitatory neurotransmitters such as glutamate and aspartate.

ADR - skin rash when dosing increased too quickly (enhanced by concurrent VPA therapy, high starting dose, rapid dose escalation), sedation

33
Q

Trileptal/Oxtellar XR

A

Oxcarbazepine

Anticonvulsant

MOA - acts presynaptically to block firing of action potentials, which decreases the release of excitatory neurotransmitters, and postsynaptically by blocking high-frequency repetitive discharge initiated at cell bodies.

ADR - HYPONATREMIA, interacts with oral contraceptives, often better tolerated

34
Q

Dilantin

A

Phenytoin

Anticonvulsant - complex partial seizures, generalized tonic clinic, status epilepticus

MOA - Blocks Na+ channels, Ca2+ blockade, NMDA blockade and increases GABA concentration

ADR - nystagmus (eye twitching), ataxia (loss of muscle control), diplopia, nausea, vomiting, constipation, hirsutism, gingival hypertrophy

35
Q

Viibryd

A

Vilazodone

SSRI

MOA - block the reuptake of serotonin back into the presynaptic neuron

ADR - headaches, diarrhea, nausea

36
Q

Topamax

A

Topiramate

Anticonvulsant - broad(er) spectrum

MOA - blockade of voltage-dependent Na+ and Ca2+ channels, other mechanisms involving glutamate

ADR - CNS (dizziness, somnolence, mental slowing confusion), renal stones, hypohidrosis (diminished sweating)

37
Q

Valproic Acid

A

Valproate

Broad spectrum - focal and generalized onset seizures

ADR - GI issues, “heartburn” - TWF, CNS, tremor, temporary hair loss, weight gain, elevated liver function lab tests

BBDA (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions