NSAIDs, Acetaminophen, DMARDS, and drugs for gout Flashcards
What does NSAID stand for?
Nonsteroidal Anti-Inflammatory Drug
Which enzyme do NSAIDs primarily inhibit?
Cyclooxygenase (COX)
True or False: NSAIDs can be used to reduce fever.
True
Fill in the blank: The two main types of COX enzymes are COX-1 and ______.
COX-2
What is the primary therapeutic effect of NSAIDs?
Anti-inflammatory, analgesic, and antipyretic effects
Which NSAID is commonly used for cardiovascular protection?
Aspirin
Multiple Choice: Which of the following is NOT a common side effect of NSAIDs? A) Gastrointestinal bleeding B) Liver damage C) Kidney damage D) Weight gain
D) Weight gain
What is the mechanism of action of NSAIDs?
Inhibition of cyclooxygenase enzymes, leading to decreased production of prostaglandins
True or False: All NSAIDs have the same risk for gastrointestinal side effects.
False
What are the common indications for NSAID use?
Pain relief, inflammation reduction, and fever reduction
Fill in the blank: The pharmacokinetics of NSAIDs includes absorption, distribution, metabolism, and ______.
Excretion
Which NSAID is often preferred for osteoarthritis due to its safety profile?
Naproxen
Multiple Choice: Which of the following NSAIDs is considered a selective COX-2 inhibitor? A) Ibuprofen B) Celecoxib C) Aspirin D) Indomethacin
B) Celecoxib
What is the primary route of excretion for NSAIDs?
Renal excretion
True or False: NSAIDs can exacerbate hypertension.
True
What is the role of prostaglandins in inflammation?
Prostaglandins promote inflammation, pain, and fever.
Fill in the blank: The half-life of many NSAIDs is typically between ______ hours.
1 to 6 hours
Which population is at higher risk for NSAID-related renal complications?
Elderly patients
What is an important consideration when prescribing NSAIDs to patients with asthma?
NSAIDs may exacerbate asthma symptoms in some patients.
Multiple Choice: Which of the following NSAIDs has the highest risk of gastrointestinal side effects? A) Aspirin B) Ibuprofen C) Naproxen D) Indomethacin
D) Indomethacin
True or False: Acetaminophen is classified as an NSAID.
False
What is the significance of the COX-2 enzyme in pain management?
COX-2 is primarily involved in inflammation and pain, making it a target for analgesic therapy.
Fill in the blank: The risk of cardiovascular events can increase with the long-term use of ______.
Certain NSAIDs
What is the primary action of NSAIDs on the gastrointestinal tract?
Inhibition of prostaglandin synthesis, leading to decreased mucosal protection.
Which NSAID is often associated with Reye’s syndrome in children?
Aspirin
Multiple Choice: Which of the following NSAIDs is a prodrug? A) Diclofenac B) Sulindac C) Ketorolac D) Meloxicam
B) Sulindac
