NSAIDS Flashcards
1
Q
Irreversible inhibition of both COX Anti inflammatory and anti platelet Pka of 3.5 ; absorbed in ileum Hydrolyzed in liver, yields salicylate Low dose assoc with low incidence of colon cancer
Adverse effects
Therapeutic : GIT disturbacnce
Large : salicylism (tinnitus, deafness, dizzines)
Toxic : uncompensted metabolic acidosis
*children : Reye’s syndrome
A
Aspirin
2
Q
Anti inflamm > analgesic compared to ASA
Less effective cox inhibitor
No platelet aggregation inhibition
A
Non acetylated salicylate (sodium salicylate and mg choline salicylate)
