Cholinergic Agonist (nicotinic) Flashcards
Acts directly on NMJ receptors and cause continuous stimulation of nicotinic NMJ
**fasciculations followed by paralysis is a hallmark
Depolarizing NMJ blocker
**reversed by atropine
Succinylcholine
ACE inhibitor
Act indirectly on nicotinic receptors. Inhibition of ACE leads to increasing acetylcholine that can stimulate NMJ receptors
**short acting and reversible
For diagnosis of myasthenia gravis
**reversal of NMJ block by nondepolarizing agent
Quaternary ammonium compounds
Endrophonium
ACE inhibitor
Act indirectly on nicotinic receptors. Inhibition of ACE leads to increasing acetylcholine that can stimulate NMJ receptors
**moderately reversible
**Used to reverse nondepolarizing NMJ blockers and treatment of myasthenia gravis
Carbamates, neostigmine, physostigmine
*physostigmine used for treatment of atropine poisoning
ACE inhibitor
Act indirectly on nicotinic receptors. Inhibition of ACE leads to increasing acetylcholine that can stimulate NMJ receptors
**irreversible
Used as insecticides. Poisoning is treated by anticholinergic drugs like atropine
Organophosphate