Cholinergic Agonist (nicotinic) Flashcards

1
Q

Acts directly on NMJ receptors and cause continuous stimulation of nicotinic NMJ
**fasciculations followed by paralysis is a hallmark

Depolarizing NMJ blocker

**reversed by atropine

A

Succinylcholine

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2
Q

ACE inhibitor
Act indirectly on nicotinic receptors. Inhibition of ACE leads to increasing acetylcholine that can stimulate NMJ receptors

**short acting and reversible

For diagnosis of myasthenia gravis

**reversal of NMJ block by nondepolarizing agent

A

Quaternary ammonium compounds

Endrophonium

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3
Q

ACE inhibitor
Act indirectly on nicotinic receptors. Inhibition of ACE leads to increasing acetylcholine that can stimulate NMJ receptors

**moderately reversible

**Used to reverse nondepolarizing NMJ blockers and treatment of myasthenia gravis

A

Carbamates, neostigmine, physostigmine

*physostigmine used for treatment of atropine poisoning

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4
Q

ACE inhibitor
Act indirectly on nicotinic receptors. Inhibition of ACE leads to increasing acetylcholine that can stimulate NMJ receptors

**irreversible

Used as insecticides. Poisoning is treated by anticholinergic drugs like atropine

A

Organophosphate

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