Glucocorticoids & Non Opiods

Question 1

Block all pathways of eicosanoid synthesis by stimulating inhibitory proteins called annexin or lipocortins

Increased neutrophils in circulation, decreased at site of inflammation
Inhibits function of tissue macrophages

**can lead to adrenal insufficiency

Answer 1

Glucocorticoids

Question 2

Weak COX1 and COX2 inhibitor
Also inhibits COX3 in CNS

absorption from oral route related to gastric emptying

NAPQI metabolite is hepato and nephrotoxic

Indications
Effective analgesic and antipyretic
No anti inflammatory and platelet inhibition
For headache, myalgia, post partum pain

Adverse : 4-6g inc liver enzymes
15g severe liver and kidney toxicity

Answer 2

Paracetamol/Acetaminophen