NSAIDS Flashcards
NSAIDS
non-steroidal anti-inflammatory drugs
Examples of common NSAIDS
- Aspirin
- Motrin
Injury → release of ______(1)____ → ____(2)____, and _____(3)____ pathways
Both lead to ____(4)____ (fever, edema, redness) and _____(5)___.
- arachidonic acid
- prostaglandin
- leukotriene
- inflammation
- pain
Cox enzyme-1
acts to help mucosa
Cox enzyme-2
acts to produce inflammation
Actions of NSAIDs
- Relieve pain
- Decrease fever
- Decrease inflammation
- Anti-coagulant
- Stop using these 2 weeks before surgery
1 S/E of NSAIDs
gastrointestional distress (heartburn, pain, bleeding)
NSAIDs can also cause these S/Es
- decrease platelet function
- tinnitus
- allergies (common)
Aspirin
Acetylsalicylc acid (ASA)
Actions of aspirin (acetylsalicylic acid)
- analgesic
- anti-pyretic (fever)
- anti-inflammatory
- anti-coagulant
Other names for Aspirin (acetylsalicylic acid)
- Aspirin
- Ecotrin
- ASA
1 S/E of Aspirin
Stomach upset
Aspirin (acetylsalicylic acid)
- Should not be given to ____(1)____ <18 years old (_____(2)____) or anyone with ____(3)___ or ulcer
- New CDC recommendation- formally 17 years
- Routes: ____(4)___ and ___(5)___
- Often ____(6)___ with other drugs like _______(7)____.
- kids
- Reye’s syndrome
- bleeding
- PO
- rectal
- mixed
- cold medications
Ibuprofen
Names
motrin
nuprin
advil
Ibuprofen actions
- analgesic
- anti-pyretic
- anti-inflammatory
Ibuprofen
What’s missing in action when compared to aspirin?
Ibuprofen is NOT highly anti-coagulant
Ibuprofen
OTC strength
200 mg/tablet
Ibuprofen S/E
Not many side effects
Ibuprofen should not be given to patients with what conditions?
- asthma
- renal disease
- hepatic disease
Route of Ibuprofen
PO only
COX-2 Inhibitors also known as
Celecoxib (Celebrex)
