NSAIDs Flashcards
Name 3 chemical mediators of inflammation.
1) kinins
2) histamine
3) neuropeptides
Give an example of a kinin.
bradykinin
Give an example of a neuropeptide.
substance P
Tissue destruction leads to release of _____ and synthesis of _____.
chemical mediators; eicosanoid mediators
Where do eicosanoid mediators derive from?
arachadonic acid
What is the target of an NSAID?
COX-1 and COX-2
By inhibiting COX1 and 2, production of ____ and ____ will decrease.
inflammatory prostaglandins; thromboxanes
COX is the major synthetic enzyme for ___ and ____.
prostaglandins (PGs); thromboxane A2 (TXA2)
What are the 4 therapeutic uses of an NSAID?
1) analgesia
2) antipyretic
3) anti-inflammatory
4) antithrombogenesis
How is analgesia achieved by an NSAID?
inhibition of inducible COX-2 at sites of tissue injury
How is an antipyretic affect achieved by an NSAID?
inhibition of inducible COX-2 in the hypothalamus
How is an anti-inflammatory affect achieved by an NSAID?
inhibition of inducible COX-2 at sites of inflammation
How is an antithrobogenesis affect achieved by an NSAID?
inhibition of constituitive COX-1 in platelets
Name 5 common side affects of NSAIDs.
1) GI ulcers, bleeding, nausea
2) increased bleeding problems
3) renal failure and nephritis
4) interference with uterine contractions
5) increased thrombotic events
Aspirin group
irreversible inhibition of COX-1 AND COX-2
traditional NSAIDs group
reversible inhibition of COX-1 and COX-2
acetaminophen group
inhibits COX-2 in CNS ONLY
cox-2 selective inhibitors group
selective reversible inhibition of COX-2 ONLY