NSAIDs

Question 1

What are the three primary medical reasons NSAIDs are used in animals?

Answer 1

1. Analgesia
2. Anti-inflammatory
3. Anti-pyretic

Question 2

What are the risks of administering NSAIDs and Glucocorticoids simultaneously?

Answer 2

Increase likelihood of side effects, esp. GI signs.

Question 3

Most common side effects of NSAIDs in the dog

Answer 3

GI Effects:
Anorexia, V/D, gastritis, enteriti, gastric ulcers/erosions.

Question 4

What organ system is of most concern when giving an NSAID to an adult cat?

Answer 4

Kidney

Question 5

What are the two types of liver toxicity caused by NSAIDs?

Answer 5

Intrinsic: dose dependent: dog gets into pill bottle
Idiosyncratic: we don’t know why

Question 6

Pros and Cons of using Aspirin for chronic pain in dogs:

Answer 6

Pros:
Inexpensive, readily available
Cons:
Incr. risk of Gi irritation/ulceration

Question 7

Why choose an NSAID over a corticosteroid for post-op pain control?

Answer 7

Fewer side effects, do not affect immune system

Question 8

How do NSAIDs work?

Answer 8

Inhibit cyclooxygenase
Newer = cox 2 selective but selectivity is dose dependent and all are non-selective at higher doses.

Question 9

What is grapiprant?

Answer 9

Galliprant
OA drug, highly selective EP4 receptor (Not COX inhibitor)
NSAID