NSAIDS Flashcards
NSAIDS is more potent than steroids
No, steroids inhibit phospholipids A2 (more potent) but NSAIDs inhibit COX
Phospholipase A2 > Arachidonic acid > COX Prostanoids
Aspirin causes vasodilation
No, anti-inflammatory blocks vasodilation
Aspirin has an analgesic ceiling
Yes, insufficient for severe pain
Reye’s syndrome
Swelling of brain and liver due to aspirin in children
Aspirin is a potent antiplatelet
Yes, irreversible cox inhibitor
Naproxen has a short half life
No, long
Why is diclonevac useful in inflammatory joint disease
Longer half life in synovial fluid
NSAIDs cause ulcer formation
Depends, if they block COX-1 more then yes bc COX-1 protects GIT
NSAIDS cause hyperkalemia and hypertension
Hypertension and hyperkalemia
COX-1 inhibition impairs wound healing, increases risk of thrombosis and causes premature closing of ductus arteriosus
No is COX-2
