Adjunct Drugs For Pain

Question 1

3 types of adjunct drugs for pain

Answer 1

1) antianxiety and muscle relaxant
-benzodiazepines

2) antidepressants
-amitriptyline

3)antiepileptics
- phenytoin, carbamazepines

Question 2

Amitripcyline mechanism of action

Answer 2

Blocks transporter at pre-synaptic membrane > increase CNS serotonin and norepinephrine post synaptic transmission

Question 3

Adverse effects of amitriptyline

Answer 3

CNS: Tachycardia, postural hypotension, cardiac arrhythmia

Anticholinergic effects: Dry mouth, blur vision, urinary retention, constipation