Anti-hypertensive Drugs

Question 1

Mechanism of diuretics

Answer 1

Inhibit NaCl reabsorption by blocking Na+/Cl- transporter at DCT > decrease blood volume > decrease BP

ENHANCE cA2+ absorption at DCT

Enhance urea reabsorption and inhibit excretion at PCT

Question 2

Adverse effects of Diuretics

Answer 2

Hyponatremia, hypokalemia

Hypercalcemia, hyperuricemia, hyperglycemia, hyperlipidemia

Question 3

Which anti-hypertensive drug is contraindicated for gout and diabetes

Answer 3

Diuretics

Question 4

Difference between propanolol and athenolol

Answer 4

Propanolol is non selective but atenolol is b1 selective

Question 5

Beta blockers can cause bradycardia and bronchospasm

Answer 5

Yes slow heart rate bradycardia

Question 6

Angiotensin converting enzyme inhibitor is contraindicated for asthma

Answer 6

NOOOO
ACE inhibitor contraindicated in pregnancy while beta blockers are contraindicated for asthma

Question 7

Lisinopril mechanism of action

Answer 7

Decreases ANG 2 by blocking conversion from ANG I > decrease vasoconstriction and decrease aldosterone > decease BP

Increases bradykinin by preventing breakdown > vasodilation > decrease blood pressure