Corticosteroids

Question 1

Effects of aldosterone (mineralcorticoids)

Answer 1

Hypernatremia, hypokalemia, metabolic alkalosis and edema

Question 2

Fludrocortisone is a synthetic analogue of …

Answer 2

Aldosterone

Question 3

Addison’s disease is…
Drug for Addison’s…

Answer 3

When excessive sodium is lost in the urine. Drug used is fludrocortisone (increase Na+ absorption into blood)

Question 4

Cortisol can lead to hypercalcemia

Answer 4

Yes, cortisol increases during hypocalcemia, causing hypertension

Question 5

Corticosteroids anti-inflammatory effects on COX-2, 5-LOX, phospholipase A2, Annexin-A1

Answer 5

Decrease COX-2, 5-LOX, phospholipase A2, increase annexin A-1 (phospholipase A2 inhibitor)

Question 6

Which corticosteroids have no mineralocorticoid water retention side effects

Answer 6

Methylprednisolone, triamcinolone, betamethasone, dexamethasone

Question 7

Corticosteroids cause allergic reactions

Answer 7

Yes! Asthma, eczema (atopic dermatitis), rhinitis

Question 8

What is the standard choice for choosing corticosteroids

Answer 8

Shorter acting steroids and little water retention (prednisolone)

Question 9

Adverse effects of corticosteroids
(Hypo/hypergluycemia), wound healing, hyper/hypocalcemia), (no) immune suppression

Answer 9

Hyperglycemia, moon face, delayed wound healing, hypocalcemia > osteoporosis, immune suppression, cataracts

Question 10

Does local corticosteroids increase systemic adverse effects

Answer 10

No, it decreases
Ointments, inhalation, nasal sprays