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Pharm Exam 1 > NSAID and APAP > Flashcards

NSAID and APAP Flashcards

1
Q

APAP clinical indications

A

fever

mild/mod pain

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2
Q

antidote for APAP OD

A

acetylcystiene

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3
Q

dose of APAP for kids

A

160mg/5mL

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4
Q

dose of APAP for adults

A

max= 1000mg

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5
Q

who gets hepatotoxicity from APAP?

A

chronic drinkers

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6
Q

does ASA help with pain?

A

no

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7
Q

Carboxylic acids

A

ASA

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8
Q

Propionic acids

A

ibuprofen

naproxen

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9
Q

who uses naproxen? why?

A

adults–longer 1/2 life

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10
Q

acetic acid derivatives

A

diclofenac

ketoralac

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11
Q

enolic acid

A

piroxicam and meloxicam

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12
Q

clinical indication for NSAID

A

inflammation
pain
fever
dysmenorrhea

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13
Q

what NSAID is only IM/IV?

A

ketorolac

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14
Q

what form should you use diclofenac in?

A

topical

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15
Q

who should not recieve NSAIDS if possible d/t risk

A

high GI or high CV risk

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16
Q

who should NEVER recieve NSAIDS?

A

AMI patients

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17
Q

what systems is diclofenac toxic to?

A

cardiac
hepatic
GI

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18
Q

labs for NSAID use

A

CBC; d/t risk of bleed

CMP; d/t renal/liver functions

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19
Q

GI ADR from nsaid

A

dyspepsia
gastritis
PUD–esp if old & on high dose

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20
Q

CV ADR from nsaid

A

thrombosis

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21
Q

lowest thrombotic risk nsaid

A

naproxen

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22
Q

highest thrombotic risk nsaid

A

diclofenac

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23
Q

what happens to asthmatics that take aspirin

A

they can have an exacerbation

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24
Q

what do NSAIDS decrease the efficacy of?

A

ACEI/ARB/diuretic

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25
Q

what do NSAIDS increase the conc. of?

A

Lithium

26
Q

what drug combination can cause AKI in those >65 y/o, or with CKD, or HF?

A

NSAID + diuretic + ARB

27
Q

how do NSAIDS interact with platelets?

A

they are anti-platelet

28
Q

if NSAIDS are anti-platelet..what drug should you be careful with?

A

warfarin

29
Q

what 3 drugs minimize GI effects of NSAIDS?

A

misoprostol
H2RA
PPI

30
Q

what NSAID is least GI toxic?

A

Ketorolac

31
Q

1st line NSAID

A

ibuprofen/naproxen

32
Q

2nd line NSAID

A

piroxicam/meloxicam

33
Q

3rd line NSAID

A

ketorolac

34
Q

4th line NSAID

A

diclofenac

35
Q

low GI + low CV risk NSAID

A

Celecoxib

36
Q

low GI risk + high CV risk NSAID

A

napoxen

37
Q

mod GI risk + low CV risk NSAID

A

celecoxib

38
Q

mod GI risk + high CV risk NSAID

A

napoxen + PPI

39
Q

high GI risk + low CV risk NSAID

A

AVOID NSAID

–if you must celecoxib + PPI or misoprostol

40
Q

high GI risk + high CV risk NSAID

A

AVOID NSAID

41
Q

what does celecoxib bind to?

A

cox 2 only

42
Q

does celecoxib bind platelets

A

NO

43
Q

what is celecoxib used in?

A

RA/OA/Sponylo/Gout–chronic pain issues

44
Q

ADR of celecoxib that is allergen

A

sulfa

45
Q

what is celecoxib a substrate of?

A

2C9

46
Q

what is the reason some Cox 2 inhibitors were removed from the market?

A

prothrombotic

47
Q

best GI NSAID=

A

celecoxib

48
Q

best heart NSAID=

A

naproxen

49
Q

3 muscle relaxants we USE

A

cyclobenzprine
baclofen
dantrolene

50
Q

cyclobenzaprine MOA:

A

identical to amytriptyline

–acts on serotinergic pathways to reduce somatic motor activity

51
Q

cyclobenzaprine clinical indications

A

msk conditions

SHORT TERM USE

52
Q

muscle relaxant with evidence for efficacy

A

cyclobenzaprine

53
Q

who shouldn’t recieve cyclobenza?

A

AMI, HF, arrhythmia pts

54
Q

dose for cyclobenzaprine?

A

5 mg

55
Q

Main ADRs for cyclobenzaprine?

A

QT prolongation
sedation
dizziness
xerostomia

56
Q

what can you NOT combine cyclobenza with?

A

CNS depressants
MAOI
TRAMADOL

57
Q

what is a rare rxn from use of carsoprodol?

A

transient quadriplegic

58
Q

what is tizanidine similar too? means we do what if we have to discontinue it?

A

clonidine–MUST taper d/t hypotension

59
Q

Baclofen clinical indications

A

MS or SC injury

60
Q

Dantrolene clinical indications

A

Malignant hyperthermia–prevention and management

61
Q

dantrolene has what ADR?

A

dose-dependent hepatotoxicity

Pharm Exam 1 (9 decks)

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