Dementia

Question 1

what do most ppl w/ neurodegenerative diseases die from?

Answer 1

infection

Question 2

best non-pharm interventions for dementia

Answer 2

low stress enviornment
daytime engagement
low noise 
low light
supplying security objects

Question 3

What cholinesterase Inhibitors is used in dementia?

Answer 3

Donepezil
Galatamine
Rivstigmine

Question 4

what should you do if pt is on drug for 8 wks w/o improvement

Answer 4

QUIT

Question 5

do the drugs fix dementia?

Answer 5

no–they do nothing to the clinical course of the disease

Question 6

what 3 things would make you consider stopping therapy?

Answer 6

no benefit noted in 3-6months
ADRs
pt is very bedridden, incontinent, nonverbal

Question 7

what should you do when discontinuing cholinesterase inhibitors?

Answer 7

TAPER

Question 8

what can you not combine cholinesterase inhibitors with?

Answer 8

anti-cholinergics (atropine, benztropine)

Question 9

major ADR of cholinesterase inhibitors?

Answer 9

bradycardia
agitation
syncope

Question 10

galatamine specific ADR

Answer 10

SJS

Question 11

rivastigmine specific ADR

Answer 11

drug overdose

Question 12

formulation of rivastigimine

Answer 12

patch

Question 13

NMDA antagonist for Dementia

Answer 13

memantine

Question 14

where does memantine work?

Answer 14

on glutamate in the cortical and hippocampal neurons