ADHD drugs Flashcards
Methylphenidate release
short
intermediate
long
DexMethylphenidate
short
long term
dextroamphetamine
short
intermediate
amphetamine-dextroamphetamine
short
long
lisdexaampthetamine
long
what is methylphendiate’s MOA
block reuptake of NE and dopamine
what is amphetamine’s MOA
promote NE and dopamine release
short acting brand names
ritalin
focalin
dexadrine
adderall
lisdezamphetamine brand name
vyvanse
unlabeled use of stimulants
depression
2ndary labeled use of vyvanse
binge-eating disorders
what drugs should you not combine stimulants with?
Anti-HTN MAOI linezolid sympathomemetics caffiene
ADR of stimulants
anorexia sleep disturbance tics slow growth rate lower seizure threshold
dosing regimen for stimulants
low and slow
who should we be careful about using stimulants in?
mania
psychosis
drug dependent ppl
ETOH dependent ppl
what should you monitor with stimulant use?
BP pulse S and S of depression, aggression, hostility growth rate signs of CNS stimulation
who needs an ECG before stimulant use?
ppl w/ pre-existing heart disease, FH, or arryhtmia
what pts shouldn’t get stimulants
anxious pts glaucoma pts underlying cardiac dz pts hyperthyroid pts pts with tics
what 3 drugs are used in ADHD that are NOT stimulants
Atomexetine
Guanfacine
Clonidine
atomoxetine MOA
SNRI
what should you not use atomoxtine with?
MAOI
linezolid
atomoxetine ADR
Suidicality HA insomnia Xerostomia N/V
when should atomoxetine be dosed?
@ night
what should be monitored with atomoxetine use?
BP HR Growth ADHD symptoms worsening agression
Guanfacine MOA
selective alpha 2 adrenergic agonist
Guanfacine shouldn’t be used w/ what other drugs
Anti-HTN
vasodilators (PDE5)
CNS depressants
Guanfacine ADRs
somnolence
hypotension
who is Guanfacine good for?
pts that can’t use stimulants aka kids w/ tics
Clonidine MOA
non-selective alpha 2 adrenergic agonist
Clonidine shouldn’t be used w/ what other drugs?
CNS depressants
CCB and BB
Anti-HTN
Vasodilators
Clonidine ADRs
sedation*****
irritability, emotionally flat, insomnia, withdrawl
what are clinical signs of true ADHD
appears in 2 + settings
significant impairment in function
tx for preschoolers
behaivor
tx for kids 6-17
behavior + meds
adderall (generic name)
amphetamine+ dextroamphetamine
ritalin or methylin (generic name)
methylphnidate
Focalin (generic name)
dexamethylphenidate
how long do short-acting drugs take
3-4hrs
how long do intermediate drugs take
6-10hrs
how long do long release drugs take
8-12 hrs
most commonly used drugs are what length?
long acting
Dexadrine or procentra (generic name)
dextroamphetamine
