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Pharm Exam 1 > Hypnotics > Flashcards

Hypnotics Flashcards

1
Q

1st gen anti-histamines?

A

Diphenhydramine

Doxylamine

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2
Q

Doxylamine clinical indiciations

A

nausea in pregnancy

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3
Q

Pearls for 1st gen antihistamines?

A

take forever to work and work forever
tolerance can develop
combined often w/ APAP

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4
Q

what drugs shouldn’t be combined w/ 1st gen anti-histamines?

A

anti-cholinergics

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5
Q

who should we avoid 1st gen anti-histamines in?

A

elderly

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6
Q

how long should someone take a break after 1st gen antihistamine use?

A

3 days

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7
Q

what TCA is good for sleep?

A

Doxepin

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8
Q

what Benzo is good for anterograde amnesia or complex sleep-related behaviors?

A

Triazolam

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9
Q

what cannot be used with hypnotic benzos?

A

3A4 inhibtors

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10
Q

Benzos used as hypnotics

A 
triazolam
estazolam
temazepam
fluazepam
Quazepam
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11
Q

3 NBRAs

A

Zaleplon
Zolpidem
Eszopiclone

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12
Q

what are NBRA’s approved for?

A

sleep onset and maintenance

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13
Q

who should have a lower dose of Zolpidem, Eszopiclone

A

elderly

females

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14
Q

what type of amine TCA is doxepin

A

tertiary

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15
Q

are NBRA’s scheduled? if so what #?

A

yes

IV

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16
Q

what is a specific ADR of eszopiclone?

A

metallic aftertaste

17
Q

what are the 3 melatonin receptor agonists?

A

Melatonin
Ramelton
Tasimelton

18
Q

what do melatonin, ramelton, tasimelon help with?

A

falling asleep

ppl w/ shift work or BLIND–circadian rhythm issues

19
Q

what are melatonin, ramelton, tasmelon substates of?

A

1A2

3A4

20
Q

drugs approved for daytime sleepiness

A

modafinil

armodafinil

21
Q

3 anti-depressants for sleep

A

trazadone
mirtazapine
amitryptaline

22
Q

2nd gen anti-psych for sleep

A

quetiapine

23
Q

AED for sleep

A

gabapentin

pregabalin

24
Q

causes of insomnia

A 
OSA
pain
depression/anxiety
caffiene
stimulants
diuretics
25
Q

1st step w/ insomnia

A

CBT

26
Q

2nd step w/ insomnia

A

pharm agent

27
Q

dosing for starting agent in insomnia

A

low and slow

28
Q

risk of using meds for insomnia

A

5x higher risk of death

29
Q

tasimelton indication

A

24 hour sleep-wake disorder

30
Q

most common NBRA used

A

zolpidem

31
Q

shortest maintenance NBRA drug

A

zaleplon

32
Q

what does agonizing MT1 cause?

A

sleepiness

33
Q

what does agonizing MT2 cause?

A

regulation of circadian rhythm

34
Q

use of ramelteon?

A

issues falling asleep

35
Q

use of tasimelton?

A

blind ppl w/o circadian rhythm–helps em out

36
Q

antidepressants that can help w/ sleep

A

trazodone
mirtazapine
amitripytline

37
Q

2nd gen Anti-psych that can help w/ sleep

A

quetiapine

38
Q

AED drugs that help w/ sleep

A

gabapentin

pregabalin

Pharm Exam 1 (9 decks)

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