November 26 - Lecture Notes Flashcards
1
Q
Sn2
A
A leaving group is replaced by a nucleophile in a single step
2
Q
What bases are better leaving groups?
A
Weak bases, such as halogens
3
Q
What happens to stereochemistry during Sn2?
A
Stereochemistry is inverted
4
Q
Factors affecting nucleophilicity
A
For atoms of similar size, stronger base = stronger nucleophile
Larger atom = better nucleophile
Steric hindrance = worse nucleophile
5
Q
Factors affecting electrophilicity
A
Less steric hindrance = better electrophile
Better leaving group (weaker base) = more reactive
6
Q
Rate law for Sn2
What affects it?
A
k[nucleophile][electrophile]
How good is the nucleophile?
How hindered is the electrophile?
How good is the leaving group?
7
Q
Rate law for Sn1
What affects it?
A
k[electrophile]
How stable is the carbocation?
How good is the leaving group?
