Notes from pubs

Question 1

Ichthyosis Vulgaris is caused by

Answer 1

loss-of-function mutation in filaggrin gene

Question 2

2 compounds that increase molecular mobility of SC lipids and proteins at moderate relative humidity

Answer 2

glyercol

urea

Question 3

Compound that specifically influences mobility of lipids

Answer 3

UCA

Question 4

activation of PPARs regulates

Answer 4

differentation
lipid synthesis
(keratinocytes)

Question 5

oat oil treatment resulted in upregulation of

Answer 5

differentiation genes
ceramide processing genes
ceramide levels

Question 6

Anionic surfactant-induced swelling _______ as pH goes down

Answer 6

decreases

Question 7

Cationic surfactant induced swellling _________ as pH goes down

Answer 7

increases

Question 8

amphoteric surfactants cause most swelling at ____ pH

Answer 8

either extreme

Question 9

Anionic surfactants mainly exhibit _______ bonding at basic pH

Answer 9

hydrophobic

Question 10

cationic surfactants mainly exhibit _______ bonding at basic pH

Answer 10

ionic bonding

Question 11

Why is swelling low at neutral pH for amphoteric surfactants

Answer 11

Lack of repulsive forces due to lack of charged head groups when hydrophobic species interact

Question 12

Stem cells of the skin

Answer 12

Interfollicular epidermal skin cells