Dandruff Flashcards
Dandruff is caused by
Malassezia feasting on sebum
Malassezia is
lipophilic yeast found in sebum rich areas of body
Malassezia contains _______ that _________
Lipases
Hydrolyze triglycerides–> sat. fatty acids
What penetrates the scalp and induces hypoproliferation
Leftover unsaturated fatty acids
Lack of synchronization between proliferation/differentiation in D/SD causes
irregular, highly invaginated corneocyte envelope structure
Penetration of SC by oleic acid results in
inflammatory response in susceptible persons
disturbs homeostasis
–>erratic cleavage of SC cells
4 sequential pathophysiological phases of D/SD
- Malassezia interaction w epidermis
- Initiation/Propagation of inflammation
- Disruption of proliferation/differentiation
- Physical/functional barrier disruption
Flaking is a result of _______ stage of dandruff
Proliferation/differentiation disruption
In P&G Study, oleic acid induced flaking in
dandruff-prone individuals only
Types of treatments for D/SD
- Keratinolytic agents
- Keratinization regulators
- antimicrobial agents
Salicylic acid and sulfur are ________ to treat dandruff
Keratinolytic
Zinc pyrithone is under the _______ category of dandruff treatment
Keratinization regulator
Selenium sulfides treat dandruff through _____ properties
antimicrobial
Dandruff prone individuals have
underlying barrier dysfunction allowing FUFA metabolites of sebum to easily penetrate the scalp
