Norton Part 7

Question 1

what is psoriasis

Answer 1

accelerated proliferation of skin cells resulting in scaling

Question 2

psoriasis occurs at what age

Answer 2

any but average is 35 years old

Question 3

psoriasis can impact what about the patient in every day

Answer 3

quality of life and self-esteem impacts can be enormous

Question 4

normally it takes 28 days for keratinocytes to move from stratum basal to shedding, in psoriasis this is how long

Answer 4

3-4 days

Question 5

well-demarcated, erythematous plaques and papule with silver scaling is seen in what

Answer 5

psoriasis

Question 6

what is Auspitz’s sign

Answer 6

pinpoint bleeding on removal of scale

Question 7

auspitz’s sign is seen in what

Answer 7

psoriasis

Question 8

what is the Koebner phenomenon

Answer 8

trauma to the skin and stress can cause exacerbation of lesions

Question 9

what histological features are seen in psoriasis

Answer 9

downward elongation of rete ridges
thinning of overlying stratum granulosum with parakeratosis above
aggregates of neutrophils with surrounding spongiosis
capillaries in dermal papillae are brought close to the surface

Question 10

erythrodermic psoriasis involves what

Answer 10

entire skin

very serious

Question 11

Guttate psoriasis involves what

Answer 11

scattered, dry-like, pink, scaly plaques

may follow strep infections

Question 12

pustular psoriasis is what

Answer 12

pustules on erythematous skin on palms/soles or generalized

Question 13

50% of patients with psoriasis what is involved

Answer 13

nails
oil spotting- focal brown discoloration of nail plate
onycholysis- distal separation of plate from bed
subungual hyperkeratosis
pitting

Question 14

pencil in cup deformity is seen in what

Answer 14

psoriatic arthritis

due to erosions

Question 15

what should one not give patients with psoriasis

Answer 15

oral steroids

Question 16

seborrheic dermatitis (“cradle cap” and dandruff) is what type of disorder

Answer 16

chronic inflammatory process affecting areas rich in sebaceous glands

Question 17

seborrheic dermatitis peaks when

Answer 17

infacny and adulthood

Question 18

what causes seborrheic dermatitis

Answer 18

yeast Malassezia furfur (normal in skin)

Question 19

seborrheic dermatitis

Answer 19

scalp
ears
eyebrows
nasolabial folds
chest

Question 20

seborrheic demratitis is more common in people with what

Answer 20

parkinsons and HIV

Question 21

what is seen in seborrheic dermatits

Answer 21

yellow, greasy, scaly patches with surrounding erythema

Question 22

Puritic, purple, polygonal, planar papules, plaques are seen in what

Answer 22

lichen planus

Question 23

what type of history would one expect to see in lichen planus

Answer 23

severe itching

Question 24

what are Wickham’s striae and what are they associated with

Answer 24

fine, reticulated, white lines

seen in lichen planus

Question 25

the koebner phenomenon is seen in what conditions

Answer 25

psoriasis | lichen planus

Question 26

what virus may be associated with lichen planus

Answer 26

hepatitis C

Question 27

what histological features are seen in lichen planus

Answer 27

interface dermatitis- dense, continuous infiltrate of lymphocytes along the dermoepidermal junction civatte bodies- incorporation of necrotic basal keratinocytes into inflamed papillary dermis dermoepidermal interface changed to a more angulated zigzag (saw-toothing) associated with degeneration and necrosis basal keratinocytes

Question 28

where is lichen planus most commonly found

Answer 28

wrists and ankles | mucus membrane involvement is common

Question 29

lichen Plans is usually self limited, how long until it resolves?

Answer 29

1-2 years after onset

Question 30

systemic lupus erythematous is what type of disease

Answer 30

autoimmune involving connective tissues and blood vessels | due to immune complex deposition (Type III)

Question 31

SLE is more common in what people

Answer 31

African Americans Females to male (9:1) 30-40 years old

Question 32

what to patients with SLE present with

Answer 32

``` skin lesions that are exacerbated in the sun fatigue fever weight loss malaise arthralgias CNS symptoms ```

Question 33

what is a malar rash

Answer 33

"butterfly rash" erythematous, confluent, macular eruption with clear borders spares nasolabial folds

Question 34

the malar rash (butterfly rash) is associated with what

Answer 34

SLE

Question 35

what systemic effects are seen in lupus

Answer 35

``` oral ulcers renal disease pericarditis pneumonitis peritonitis hepatosplenomegaly myopathy neuropathy lymphadenopathy seizures ```

Question 36

SLE gives what results on RPR and VDRL

Answer 36

false positive

Question 37

what histological features are seen in SLE

Answer 37

lichenoid interface dermatitis epidermal atrophy thickening of basal membrane