Nonbezodiazepine Hypnotics Flashcards

1
Q

Name the 3 drugs belonging to this class.

A

Zolpidem
Zaleplon
Eszopiclone

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2
Q

Clinical use of nonBZD hypnotics?

A
  • sleep disorders, esp when sleep onset is delayed
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3
Q

Mechanism of action of nonBZD hypnotics.

A

They bind to GABA-A receptor sites (close to BZD site)

-facilitate chloride channel opening

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4
Q

What other NBZD drugs can be used in sleep disorders? (Also with little side effects)

A

Melatonin Receptor Agonists

Ramelteon, Tasimelteon

activate MT1 and MT2 receptors in suprachiasmatic nucleus

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