Drugs Acting On RAAS System

Question 1

What is the dose of enalapril given for treating hypertension ?

Answer 1

Enalapril = ACE inhibitor

1x 5-20 mg

Question 2

What is the dose of valsartan give to treat hypertension?

Answer 2

Valsartan = ARB

1x 80-320 mg

Question 3

Name at least 3 ACE inhibitors.

Answer 3

Captopril, Lisinopril (active drugs)

Enalapril, Fosinopril (prodrugs)

Question 4

What are the “first-line group of drugs” used to treat hypertension ? Name 4.

Answer 4

Thiazide diuretics, ACE inhibitors, angiotensin receptor blockers, calcium channel blockers

Question 5

Name the drug that directly inhibits Renin.

Answer 5

Aliskiren

Question 6

Name some beta blockers that can be used for the treatment of hypertension (&HF).

Answer 6

B1 selective blockers : Atenolol, metoprolol
Non selective : propranolol
Carvedilol - also blocks alpha 1receptors
Nebivolol - also releases nitric oxide

Question 7

Name 2 centrally acting sympathoplegic drugs that can be used in the treatment of hypertension.

Answer 7

These are alpha2 receptor agonists.

CLONIDINE, methyldopa (used mainly for HTN in pregnancy)

Question 8

What drug should an ACE inhibitor NOT be combined with?

Answer 8

Potassium sparing diuretic !

e.g Amiloride