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Pharma > Antimycobacterial Antibiotics > Flashcards

Antimycobacterial Antibiotics Flashcards

1
Q

The first line drugs for TB, in order of their frequency of use are …

A

Isoniazid (INH)
Rifampin
Pyrazinamide

Ethambutol
Streptomycin

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2
Q

Most severe adverse effect of Isoniazid, Rifampin, Pyrazinamide?

A

Hepatotoxicity

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3
Q

Isoniazid mechanism of action.

A

Inhibits synthesis of mycolic acid component of cell wall of Mycobacteria.

Bactericidal

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4
Q

Rifamycins drugs include?

A

Rifampin
Rifabutin
Rifapentine

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5
Q

Mechanism of action of Rifampin.

A

Inhibits DNA dependent RNA polymerase

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6
Q

Streptomycin mechanism of action.

A

It belongs to the aminoglycosides.

  • inhibits protein synthesis at the 30s subunit
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