Non-Malignant Causes of Leukocytosis Flashcards
leukocytosis - clinical definition
*a total WBC count > 11K
leukocytosis with neutrophilia
*WBC > 11K and absolute neutrophil count (ANC) > 7.7K
*note: ANC = # of PMNs and # of bands
non-malignant causes of leukocytosis with neutrophilia
*infection
*stress (physical, emotional)
*smoking
*pregnancy
*post-exercise setting
*myocardial infarction
*generalized marrow stimulation (hemolysis, IDA)
what are the 6 neutrophil storage pools?
*bone marrow:
-mitotic pool
-maturation pool
-storage pool
*peripheral blood:
-circulating pool
-marginated pool
*tissue pool
what 2 chemicals (medications) can result in neutrophilia
- G-CSF
- GM-CSF
leukocytosis with bandemia
*WBC > 11K and absolute band count > 0.7K
*“left shift”
*seen in acute bacterial infections
*should NOT see more immature cells on differential
2 causes of lymphocytosis
*lymphocytosis is defined as absolute lymphocyte count > 4.8K
*MAIN CAUSE = VIRAL INFECTION (EBV, CMV, HIV, mumps, varicella, influenza, etc)
*non-viral causes:
-bordetella pertussis (whooping cough)
-bartonella henselae (cat scratch disease)
-toxoplasmosis
-babesiosis
*non-infectious causes:
-hypersensitivity reactions
-stress
leukocytosis with monocytosis
*WBC > 11K and absolute monocyte count > 0.8K
*can be seen in acute bacterial infection, TB, or after GM-CSF administration
*uncommon
3 types of eosinophilia
- primary eosinophilia = malignancy
- secondary eosinophilia = infectious (esp parasites or aspergillus); non-infection (allergic disorders, meds, etc)
- idiopathic eosinophilia = unknown cause
leukocytosis with basophilia
*causes include:
-hypersensitivity reactions
-ulcerative colitis
-rheumatoid arthritis
-hypothyroidism
-exogenous estrogen supplementation
-infections (viral, TB, helminths)
pseudo-neutropenia
*increased percentage of neutrophils marginated against endothelial vessel walls
*still able to demarginate when needed
*no history of difficulty fighting infection
infection as a cause of neutropenia
*particularly VIRAL infections can cause a transient neutropenia
*mononucleosis, hep B, and HIV can cause more protracted courses of neutropenia
*mechanisms include:
-marrow suppression
-upregulation of adhesion and migration due to complement and cytokine release
medication-induced neutropenia
*over 100 drugs implicated
*mechanisms:
-immune mediated: metabolite of drug binds to neutrophil (or precursor) membrane and antibodies or T cells destroy the cell
-direct toxicity: neutrophils (or precursors) metabolize drug to toxic compound that results in cell death
immune-mediated neutropenia
*anti-neutrophil antibodies (or antibodies to neutrophil precursors)
*can be seen with other immune-mediated disorders:
-autoimmune mediated hemolytic anemia
-immune mediated thrombocytopenia
-autoimmune disorders
causes of lymphopenia
*decreased production:
-VIRAL INFECTIONS
-immunodeficiency diseases (AIDS, aplastic anemia)
*increased destruction
*congenital disorders