Non-Malignant Causes of Leukocytosis Flashcards

1
Q

leukocytosis - clinical definition

A

*a total WBC count > 11K

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2
Q

leukocytosis with neutrophilia

A

*WBC > 11K and absolute neutrophil count (ANC) > 7.7K
*note: ANC = # of PMNs and # of bands

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3
Q

non-malignant causes of leukocytosis with neutrophilia

A

*infection
*stress (physical, emotional)
*smoking
*pregnancy
*post-exercise setting
*myocardial infarction
*generalized marrow stimulation (hemolysis, IDA)

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4
Q

what are the 6 neutrophil storage pools?

A

*bone marrow:
-mitotic pool
-maturation pool
-storage pool

*peripheral blood:
-circulating pool
-marginated pool

*tissue pool

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5
Q

what 2 chemicals (medications) can result in neutrophilia

A
  1. G-CSF
  2. GM-CSF
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6
Q

leukocytosis with bandemia

A

*WBC > 11K and absolute band count > 0.7K
*“left shift”
*seen in acute bacterial infections
*should NOT see more immature cells on differential

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7
Q

2 causes of lymphocytosis

A

*lymphocytosis is defined as absolute lymphocyte count > 4.8K
*MAIN CAUSE = VIRAL INFECTION (EBV, CMV, HIV, mumps, varicella, influenza, etc)

*non-viral causes:
-bordetella pertussis (whooping cough)
-bartonella henselae (cat scratch disease)
-toxoplasmosis
-babesiosis
*non-infectious causes:
-hypersensitivity reactions
-stress

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8
Q

leukocytosis with monocytosis

A

*WBC > 11K and absolute monocyte count > 0.8K
*can be seen in acute bacterial infection, TB, or after GM-CSF administration
*uncommon

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9
Q

3 types of eosinophilia

A
  1. primary eosinophilia = malignancy
  2. secondary eosinophilia = infectious (esp parasites or aspergillus); non-infection (allergic disorders, meds, etc)
  3. idiopathic eosinophilia = unknown cause
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10
Q

leukocytosis with basophilia

A

*causes include:
-hypersensitivity reactions
-ulcerative colitis
-rheumatoid arthritis
-hypothyroidism
-exogenous estrogen supplementation
-infections (viral, TB, helminths)

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11
Q

pseudo-neutropenia

A

*increased percentage of neutrophils marginated against endothelial vessel walls
*still able to demarginate when needed
*no history of difficulty fighting infection

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12
Q

infection as a cause of neutropenia

A

*particularly VIRAL infections can cause a transient neutropenia
*mononucleosis, hep B, and HIV can cause more protracted courses of neutropenia
*mechanisms include:
-marrow suppression
-upregulation of adhesion and migration due to complement and cytokine release

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13
Q

medication-induced neutropenia

A

*over 100 drugs implicated
*mechanisms:
-immune mediated: metabolite of drug binds to neutrophil (or precursor) membrane and antibodies or T cells destroy the cell
-direct toxicity: neutrophils (or precursors) metabolize drug to toxic compound that results in cell death

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14
Q

immune-mediated neutropenia

A

*anti-neutrophil antibodies (or antibodies to neutrophil precursors)
*can be seen with other immune-mediated disorders:
-autoimmune mediated hemolytic anemia
-immune mediated thrombocytopenia
-autoimmune disorders

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15
Q

causes of lymphopenia

A

*decreased production:
-VIRAL INFECTIONS
-immunodeficiency diseases (AIDS, aplastic anemia)
*increased destruction
*congenital disorders

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