Anaplastic Large Cell Lymphoma

Question 1

anaplastic large cell lymphoma - cell lineage

Answer 1

T cells (therefore, it would have a TCR gene rearrangement)

Question 2

anaplastic large cell lymphoma - appearance

Answer 2

mutlinucleated “wreath cell”

Question 3

anaplastic large cell lymphoma - genotype

Answer 3

t(2;5) with ALK-NPM gene

Question 4

anaplastic large cell lymphoma - gene (fusion protein)

Answer 4

ALK-NPM (nucleophosmin) gene [result of t(2;5)]