Clinical Pharm - Chemo 1

Question 1

2 main classes of anti-cancer agents & their MOA

Answer 1

1. traditional cytotoxic chemotherapy
   MOA: kills any cell that is rapidly dividing
2. targeted therapy
   -monoclonal antibodies bind to a specific antigen [-mab]
   -small molecule that inhibits a specific protein (ex. tyrosine kinase inhibitors) [-nib/-mib/-lib]

note - traditional cytotoxic chemo has a worse side effect profile than targeted therapy

Question 2

what are the risk factors for methotrexate toxicity?

Answer 2

*concomitant medications
*pre-existing renal dysfunction
*Down Syndrome
*third space fluids

Question 3

what is the rescue drug for high dose methotrexate

Answer 3

leucovorin

Question 4

what is the standard induction chemotherapy regimen for AML?

Answer 4

7 + 3 - cytarabine and daunorubicin