Non-hodgkins Lymphoma

Question 0

Chromosomal translocations for mantle cell lymphoma

Answer 0

t(11;14), cyclin D1 over expression

Question 1

Chromosomal translocations for Follicular lymphoma

Answer 1

t(14;18), over expression BCL 2

Question 2

Chromosomal translocations for Burkitt lymphoma

Answer 2

t(2;8),t(8;14), and t(8;22), fuse Ig gee to c-myc

Question 3

Chromosomal translocations for DLBCL

Answer 3

Germinal center type: over express BCL6 mRNA

Post germinal center type: over express BCL 2 mRNA, poor prognosis

Question 4

Chromosomal translocations for anaplastic large cell lymphoma

Answer 4

t(2;5), alk gene fusion with nucleophosmin

Question 5

Chromosomal translocations for marginal zone lymphoma

Answer 5

t(11;18), MALT 1 translocation

Question 6

Germinal center DLBCL

Answer 6

Cd 10+, Mum 1 negative, BCL 6 +

Better prognosis

Question 7

Non-germinal center DLBCL

Answer 7

Cd 10-, mum 1 positive, bcl2 positive

Worse prognosis

Question 8

Peripheral T cell lymphoma

Answer 8

CD 3 and 43 positive
Kappa it lambda negative (rules out B cell)
Cd 20, 30, 34, 56 negative

Question 9

Aggressive NK cell leukemia/lymphoma

Answer 9

CD 45 and 55 positive 
Cd 3,4,5,8,20 negative 
B and T cell gene rearenagements negative
Ebv positive 
Often presents with dic

Question 10

Large granular lymphocyte leukemia

Answer 10

Rheumatoid arthritis, fever, neutropeniA, splenimegaly
TdT, cd 3,8,56,57 positive
Tx with mtx, cyclophosphamide chlorambucik or steroids