AML

Question 0

M1–AML without maturation

Answer 0

Cytogenetics

Question 1

M0–minimally differentiated acute myeloblastic leukemia

Answer 1

Cytogenetics

Question 2

M2-AML with granulocytic maturation

Answer 2

Cytogenetics

t(8;21)(q22; q 22), t(6;9)

Question 3

M3-acute promyelocytic leukemia

Answer 3

t(15;17)
Cd 34-
Hla-dr -

Question 4

M4-acute myelomonocytic leukemia

Answer 4

Inv(16)(p13q22), del(16)

Question 5

M4eo–myelomonocytic with marrow eosinophilia

Answer 5

Inv (16), t(16;16)

Question 6

M5–acute monoblastic leukemia 5a

Or acute monocytic leukemia 5b

Answer 6

Del(11q), t(9;11) MLL, t(11;19)

Question 7

M6–acute erythroid leukemia

Answer 7

Cyto

Question 8

M7-acute megakaryoblastic leukemia

Answer 8

T(1;22) children
3q in adults
CD 41+

Question 9

M8-acute basophilic leukemia

Answer 9

Cyto

Question 10

Aml favorable

Answer 10

T(8;21), t(15;17)
Inv 16 c-kit wild type
CEBPA positive
NMP1 positive
Fly 3 negative

Question 11

Aml intermediate

Answer 11

Normal Cytogenetics
T(9;11)
Trisomy 8

Question 12

Aml unfavorable

Answer 12

Complex Cytogenetics >3
Flt 3 itd positive 
Inv 3
T(6;9)
Del 5q
Del 7q
T(11q23)
MLL mutation

Question 13

TdT positive

Mpo negative

Answer 13

Aml M0 (no auer rods)
Aml M1. (Has auer rods)
ALL

Question 14

CD 41 positive aml

Answer 14

M7 megakaryocytic leukemia

Question 15

APL immunophenotype

Answer 15

T(15;17)(q22;12); PML-rara
Cd 34 negative or weak
HLA-DR negative
CD 13 positive
CD 11b negative

Question 16

Aml m5

Answer 16

Gingival hypertrophy
Blasts monocytic
MPO negative
T(9;11)

Question 17

Aml m7 megakaryocytic leukemia

Answer 17

Cd 41 positive
Cd 61 positive
Marrow fibrosis
T(1;22)

Question 18

Generalization:

Dry tap suggests…

Answer 18

Aml M7
Hairy cell leukemia
ALL

Question 19

Immunophenotype B-cell ALL

Answer 19

TdT positive
HLA-DR positive
Cd 19 positive
Cd 79a positive
Cd 10 positive
Cd 22 positive

Question 20

Immunophenotype T cell ALL

Answer 20

TdT positive 
Cd7 positive usually
Cytoplasmic cd 3 positive
Cd 4 positive
Cd 8 positive

Question 21

Mature B cell ALL, burkitts

Answer 21

Emergency
Expresses surface immunoglobulin
CD 20 POSITIVE

Question 22

Myeloid markers that can be positive on ALL

Answer 22

Cd 15, cd 33, cd 65 positive in MLL mutation

Cd 13, cd 33 TEL-AML1 fusion–> t(1;19)

Question 23

Prognostic translocation a in ALL
Hypodiploidy (5 chrom)
T(12;21)
Hyperdiploidy (>50 chrom)

Answer 23

Hypodiploidy (5 chrom) POOR
T(12;21) GOOD
Hyperdiploidy (>50 chrom) GOOD