Non Hodgkin Lymphoma Flashcards
i) Malignancy of hematopoietic cells
ii) Starts in bone marrow, can spread to blood, nodes
iii) Myeloid or lymphoid
iv) Acute or chronic
a) Leukemia
i) Malignancy of hematopoietic cells
ii) Starts in lymph nodes, can spread to blood, marrow
iii) Lymphoid only
iv) Hodgkin or non-Hodgkin
b) Lymphoma
a) Malignant proliferation of lymphoid cells (blasts or mature cells) in lymph nodes
b) Skips around
c) Many subtypes
d) Most are B cell
5) Non-Hodgkin Lymphoma
a) Small mature lymphocytes
b) Same thing as CLL
c) B-cell lesion, but CD5+ (weird!)
d) Long course; death from infection
e) Richter’s transformation – worse prognosis – turn into large cells
10) Small Lymphocytic Lymphoma
a) Actually a bunch of lymphomas
b) Marginal zone pattern
c) Malt lymphoma
d) Associated with Helicobacter pylori
e) Marginal zone pattern
11) Marginal Zone Lymphoma
a) Mantle zone pattern
b) Small angulated lymphocytes
c) t(11;14) – cyclin D1 and IgH
d) More aggressive
12) Mantle Cell Lymphoma
a) Follicular pattern (later diffuse)
b) Small cleaved cell, mixed or large cell
c) Grade 1, 2, or3
d) t(14;18) - IgH and bcl-2
e) “but cells” – clefted cells
13) Follicular Lymphoma
a) Skin lesions
b) Blood involvement
c) Cerebriform lymphocytes
d) T-cell immunophenotype
e) Pautrier microabscess in skin
15) Mycosis Fungoides/Sézary Syndrome (mushrooms mushrooms)
a) Large B cells
b) Extranodal involvement
c) Grows rapidly
d) Bad prognosis
16) Diffuse Large-Cell Lymphoma
a) Two types: B and T
b) Lymphoblasts in diffuse pattern
c) Same as ALL
d) T-lymphoblastic lymphoma often in teenage male with mediastinal mass
17) Lymphoblastic Lymphoma
a) Child with fast-growing, extranodal mass
b) Starry-sky pattern
c) t(8;14) = c-myc and IgH
d) Occasionally involves blood
18) Burkitt Lymphoma
a) Japan/Caribbean basin
b) Associated with HTLV-1 virus
c) Skin lesions, hypercalcemia
d) Very aggressive
19) Adult T-Cell Leukemia/Lymphoma – rare
