Non-covalent interactions

Question 1

Types of non-covalent interactions

Answer 1

Peptides interact with each other via non-covalent interactions occurring on:
a)Peptide bonds (because of H-bonding)

b)R-groups (H-bonding, hydrophobic interaction and ionic interaction)

c)Terminal NH3+ , COO-CH-bonding, ionic interaction)

Question 2

a) The peptide bond can interact with other molecules via hydrogen bonding

Answer 2

The partially negative charged oxygen atom on one peptide bond can H-bond wih the partially positively charge H atom on another peptide bond

Question 3

b) R-groups can interact with other molcules via H-bonding, hydrophobic interactions and ionic interactions

Answer 3

Example: The negatively charge O atom on the R-group of (glutamic) acid can form ionic interaction with the NH3+ on the R-group of lysine