Non Biologic Treatments Psoriasis Flashcards
What is the dosing for Acitretin?
10-50 mg QD
Acitretin is used in the treatment of psoriasis.
What is the dosing for Apremilast?
30 mg BID after titration
Apremilast is an oral agent for psoriasis.
What is the dosing for Cyclosporine?
1.25-2.5 mg/kg BID
Cyclosporine is used for severe cases of psoriasis.
What baseline and ongoing tests are required for monitoring when using acitretin therapeutics?
CBC, lipid profile, LFTs, renal function tests, pregnancy test
Ongoing monitoring is crucial to assess safety and efficacy. Category X pregnancy, contraindicated, severe liver and kidney disease. Or chronically elevated lipids.
What pregnancy category is assigned to acitretnin and methotrexate?
Category X
It is contraindicated in pregnancy.
What are monitoring parameters for Cyclosporine?
Baseline and ongoing:
blood pressure, BUN, creatinine, urinalysis, TB, LFTs, CBC, lipid profile, uric acid, magnesium, potassium, pregnancy test
Do not use for > 1yr continuously
What common adverse reactions are associated with acitretin?
Dry mouth, eyes, skin, hypertriglyceridemia, mood changes, hair loss, headache
Monitoring for these effects is necessary.
What are the ongoing considerations when using apremilast?
Weight loss, new or worsening depression/mood changes
What is the dosing for Methotrexate? And what is often also prescribed?
7.5-25 mg QW after titration
Methotrexate is often used in conjunction with folate. Consider concomitant folate 1-5 mg QD to help with side effect tolerance
What are absolute contraindications for Methotrexate?
Pregnancy, nursing mothers, alcoholism, hepatic disease, immunodeficiency syndromes
These conditions pose significant risks when using Methotrexate.
What common adverse reactions are associated with Methotrexate?
Hepatotoxicity, pulmonary toxicity, cytopenias, nausea, vomiting, fatigue, ulcerative stomatitis, hair loss
Regular monitoring is essential to manage these risks.
What is a relative contraindication for Methotrexate?
Abnormal liver or renal function, active infection, obesity, diabetes
These conditions may require careful consideration before treatment.
True or False: Concomitant folate 1-5 mg is recommended with Methotrexate to help with side effects.
True
Folate can improve tolerance to Methotrexate.
Fill in the blank: Cyclosporine should not be used for _______ continuously.
more than 1 year
Long-term use can lead to increased risks of adverse effects.
