Cosemtic Neurotoxins

Question 1

OnabotulinumtoxinA (Botox) is FDA approved for what 3 areas? What are the recommended doses and muscle groups?

Answer 1

1. Mod-severe glabella (20 units), corrugator and/or proceeds muscle activity
2. Mod- severe lateral canthal lines (24 units), obicularis oris
3. Mod-severe forehead lines (40 units), frontalis

Question 2

AbovotulinumtoxinA (dysport) has FDA clinical indication for what area(s) and dosing? What is a unique contraindication for this toxin?

Answer 2

• Moderate to severe glabellar lines in adults <65
• Dosing-50units
• contraindicated in pts with cows milk protein allergy

Question 3

IncobotulinumtoxinA (Xeomin) is FDA approved for what area(s), what is the dosing?

Answer 3

Moderate to severe glabellar lines
20 units

Question 4

prabotulinumtoxinA-xvfs (jeuveau) is FDA approved for what area(s), what population and how many units?

Answer 4

Mod to severe glabellar lines
Adults (not defined age)
20 units

Question 5

Daxibotulinumtoxin-A (Daxxify) is FDA approved for what area(s), what is the dose, and what is the difference in this toxin? What is a theoretical unique adverse effect (AE)?

Black box warning?

Answer 5

Moderate severe glabellar lines
40 units
Durability of response 6 months
Adverse effect-amininoglycoside antibiotics, anticholinergic agents or any others agents many interfere with neuromuscular transmission may potentials the effects.

BBW- distant spread of toxin effects reported weeks after injection. Swallowing and breathing difficulties can be life threatening and deaths have been reported. Not approved for other special consistions.