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Drugs, Biologics, Dermatology, DCNP Exam > Biologics Psoriasis > Flashcards

Biologics Psoriasis Flashcards

1
Q

What are TNF Alpha Inhibitors?

A

A class of medications used to treat autoimmune diseases by blocking tumor necrosis factor alpha

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2
Q

Name TNF Alpha Inhibitors

A

Etanercept (enbrel)
Adalimumab (humira)
Cetrolizumab (cimzia) ok preg
Golimumab (simponi)
Infliximab (remicade)

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3
Q

What is the trade name for Adalimumab?

A

Humira

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4
Q

Which TNF Alpha Inhibitors are indicated for both Psoriasis (PsO) and Psoriatic Arthritis (PsA)?

A

Entanercept
Adalimumab
Cetrolizumab
Infliximab

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5
Q

What are common side effects (SEs) of TNF Alpha Inhibitors?

A

All: Infections, Injection Site Reactions (ISR)

Rash:Adalimumab and Cetrolizumab

HTN: golimumab

Infusion related reaction and abdominal pain: infliximab

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6
Q

Which TNF Alpha Inhibitor has the indication for PsO and is associated with the lowest risk in pregnancy and lactation?

A

Certolizumab pegol

Known by the trade name Cimzia

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7
Q

What serious adverse effects (AEs) are associated with TNF Alpha Inhibitors?

A

Serious infections, Fungal infections, Hepatitis B reactivation, New/worsening heart failure, Low blood count, Lupus-like syndrome, Lymphoma, other malignancies

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8
Q

What are the absolute contraindications for TNF Alpha Inhibitor therapy?

A

Hypersensitivity, Active infection, Chronic infection (including TB), Concurrent administration with anakinra

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9
Q

Fill in the blank: The trade name for Infliximab is _______.

A

Remicade

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10
Q

What are relative contraindications for TNF Alpha Inhibitor therapy?

A

Congestive heart failure, Family history of demyelinating disease (ie MS), History of malignancies or lymphoma

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11
Q

What common side effects are associated with Infliximab?

A

Infections, Headache, Infusion-related reactions, Abdominal pain

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12
Q

What type of therapy is Ustekinumab (Stelara)?

A

IL-12/23 inhibitor
Targeted Biologic Therapy

Approved for Psoriasis (PSO) and Psoriatic Arthritis (PsA) for patients ≥ 6 years.

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13
Q

What are common side effects of Ustekinumab ( stelara)?

A

Cold or flu-like symptoms, URI, HA, fatigue

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14
Q

What are the types of IL-17a inhibitors mentioned?

A
  • Secukinumab (Cosentyx)
  • Ixekizumab (Taltz)
  • Brodalumab (Siliq)

IL-17a inhibitors are used in the treatment of psoriasis and psoriatic arthritis. Except brodalimumab

Cosentyx and taltz >6

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15
Q

What are the names of IL-23 inhibitors listed?

A
  • Tildrakizumab (Ilumya)
  • Risankizumab (Skyrizi)
  • Guselkumab (Tremfya)

IL-23 inhibitors are utilized for treating psoriasis and PsA except tildrakizumab

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16
Q

What is the generic name for Xeljanz?

A

Tofacitinib

Tofacitinib is a Janus Kinase (JAK) inhibitor for Psoriatic Arthritis (PsA).

17
Q

What are common side effects of Tofacitinib?

A

HA, nausea, URI, vomiting

18
Q

What are the warnings/precautions for IL12/23?

A
  • Serious infections (especially mycobacteria, salmonella, BCG vaccinations)
  • Malignancies
  • Posterior leukoencephalopathy

Patients should be screened for infections including TB.

19
Q

What are the absolute contraindications for IL-17a inhibitor?

A
  • Known hypersensitivity
  • Active infection
  • Chronic infection including TB
  • patients with inflammatory bowel disease.

Other- bridalumab-rems- depression si

20
Q

True or False: Brodalumab has a risk of depression and requires a REMS program.

A

True

REMS stands for Risk Evaluation and Mitigation Strategy.

21
Q

Fill in the blank: IL-17a inhibitors are used in the treatment of _______.

A

psoriasis and psoriatic arthritis

22
Q

What serious risks are associated with JAKs?

A
  • Serious infections
  • Mortality
  • Malignancy
  • Major adverse cardiovascular events (MACE)
  • Thrombosis
    Elevated liver enzymes, whipped, anemia, lymphoma, and other malignancies. G.I. perforations and ulcerations.
    Close monitoring is advised for patients on these therapies.
23
Q

What type of infection screening is required before starting treatment?

A

Screening for tuberculosis (TB)

This is crucial for patients receiving immunosuppressive therapies.

24
Q

What is the risk associated with combining targeted therapies with TNF inhibitors?

A

Increased risk of serious infections

This combination therapy should be approached with caution.

Drugs, Biologics, Dermatology, DCNP Exam (4 decks)

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