NON-beta lactam Antibiotics

Question 1

Cotrimoxazole made from

Answer 1

Trimethoprim

Sulfamethexazole

Question 2

Cotrimoxazole given as

Answer 2

Oral

Has CSF crossing

Question 3

Aminoglycosides cannot be used for

Answer 3

Pregnant women

Question 4

Highest bioavailability for tetracyclines

Answer 4

Long acting

Excreted via biliary (only exception)

Question 5

Atypical athogens where tetracyclines are active

Answer 5

CML
Chlamydia
Mycoplasma
Legionella

Question 6

What are the long acting tetracyclines

Answer 6

DMT
Doxycycline
Minocycline
Tigecycline

Question 7

Clinical uses of tetracyclines

Answer 7

Chlamydia infections
Mycoplasma pneumonia
Cholera short term therapy
Leptospirosis
Actinomycosi
2nd line for malaria

Question 8

Medmonic for tetracyclines

Answer 8

Puro C
Children - avoid
Childbirth -contrindication
Cholera
Chlamydia
Chelator - Ca2+/Mg2+

Question 9

Antimicrobials that bind to 50S ribosomal subunit

Answer 9

MCC
macrolides
Chloramphenicol
Clindamycin

Question 10

Clarithromycin vs erythromycin

Answer 10

More gram neg activity by clarithromycin

All plus H. influenza and M. catarrhalis

Question 11

Use for whooping cough (Bordetella pertussis)

Answer 11

Macrolides

Question 12

With side effect ototoxicity

Answer 12

Aminoglycosides
Macrolides
Vancomycin

Question 13

Macrolides are INHIBITORS of

Answer 13

CYP1A2

CYP3A3/4

Question 14

PenPACC: MACROLIDES

Answer 14

Penicillin hypersensitivity
Pertussis
Atypical
Campylobacter
Corynbacterium

Question 15

1st line drug for community acquired MRSA

Answer 15

Clindamycin

Question 16

MOA of 50S binders

Answer 16

Inhibit translocation
Macrolides
Clindamycin

Inhibit transpeptidation
Chloramphenicol

Question 17

For chloramphenicol there are two ways to administer

Answer 17

Palmitate : oral

Succinate : IV (less bioavailability)

Question 18

Common causes of meningitis

Answer 18

S. pneumoniae
H influenza
N meningitides

Question 19

Chloramphenicol

Answer 19

Hashram neg activity with pseudomonas (not aeruginosa)

Question 20

Fantastic drug that crosses the bbb

Answer 20

Chloramphenicol

Question 21

First line drug of meningitis in developing countries

Answer 21

Chloramphenicol

Question 22

Quinolones

Answer 22

Synthetic fluorinated analogs of napidixic acid

Question 23

1st gen quinolones

Answer 23

Nalidixic acid

Cinoxin

Question 24

2nd gen quinolones

Answer 24

Ciprofloxacin

Ofloxacin

Question 25

3rd gen quinolones

Answer 25

Gatifloxacin
Levofloxacin
Moxifloxacin

Question 26

4th gen quinolones

Answer 26

Trovafloxavin (activity with anaerobes)

Off the market due to liver toxicity

Question 27

Macrolides adverse effect

Answer 27

Ventricular arrythmia
Polong QT interval
Bradycardia
Hypotension with IV administration