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Ther 201 > NON-beta lactam Antibiotics > Flashcards

NON-beta lactam Antibiotics Flashcards

1
Q

Cotrimoxazole made from

A

Trimethoprim

Sulfamethexazole

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2
Q

Cotrimoxazole given as

A

Oral

Has CSF crossing

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3
Q

Aminoglycosides cannot be used for

A

Pregnant women

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4
Q

Highest bioavailability for tetracyclines

A

Long acting

Excreted via biliary (only exception)

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5
Q

Atypical athogens where tetracyclines are active

A

CML
Chlamydia
Mycoplasma
Legionella

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6
Q

What are the long acting tetracyclines

A

DMT
Doxycycline
Minocycline
Tigecycline

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7
Q

Clinical uses of tetracyclines

A 
Chlamydia infections
Mycoplasma pneumonia
Cholera short term therapy
Leptospirosis
Actinomycosi
2nd line for malaria
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8
Q

Medmonic for tetracyclines

A 
Puro C
Children - avoid
Childbirth -contrindication
Cholera
Chlamydia
Chelator - Ca2+/Mg2+
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9
Q

Antimicrobials that bind to 50S ribosomal subunit

A

MCC
macrolides
Chloramphenicol
Clindamycin

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10
Q

Clarithromycin vs erythromycin

A

More gram neg activity by clarithromycin

All plus H. influenza and M. catarrhalis

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11
Q

Use for whooping cough (Bordetella pertussis)

A

Macrolides

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12
Q

With side effect ototoxicity

A

Aminoglycosides
Macrolides
Vancomycin

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13
Q

Macrolides are INHIBITORS of

A

CYP1A2

CYP3A3/4

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14
Q

PenPACC: MACROLIDES

A 
Penicillin hypersensitivity
Pertussis
Atypical
Campylobacter
Corynbacterium
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15
Q

1st line drug for community acquired MRSA

A

Clindamycin

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16
Q

MOA of 50S binders

A

Inhibit translocation
Macrolides
Clindamycin

Inhibit transpeptidation
Chloramphenicol

17
Q

For chloramphenicol there are two ways to administer

A

Palmitate : oral

Succinate : IV (less bioavailability)

18
Q

Common causes of meningitis

A

S. pneumoniae
H influenza
N meningitides

19
Q

Chloramphenicol

A

Hashram neg activity with pseudomonas (not aeruginosa)

20
Q

Fantastic drug that crosses the bbb

A

Chloramphenicol

21
Q

First line drug of meningitis in developing countries

A

Chloramphenicol

22
Q

Quinolones

A

Synthetic fluorinated analogs of napidixic acid

23
Q

1st gen quinolones

A

Nalidixic acid

Cinoxin

24
Q

2nd gen quinolones

A

Ciprofloxacin

Ofloxacin

25
Q

3rd gen quinolones

A

Gatifloxacin
Levofloxacin
Moxifloxacin

26
Q

4th gen quinolones

A

Trovafloxavin (activity with anaerobes)

Off the market due to liver toxicity

27
Q

Macrolides adverse effect

A

Ventricular arrythmia
Polong QT interval
Bradycardia
Hypotension with IV administration

Ther 201 (6 decks)

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