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Ther 201 > Adrenergic Agents and Blockers > Flashcards

Adrenergic Agents and Blockers Flashcards

1
Q

sympathetic

A

adrenergic

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2
Q

sympathomimetic

A

adrenergic agonists

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3
Q

sympatholytic

A

adrenergic ANTAGonists

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4
Q

sympathomimetic

A

mimic e/norE (catecholamines)

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5
Q

norE

A

nerve terminals (n:n)

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6
Q

epinephrine

A

adrEnal mEdulla (eEE)

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7
Q

NE transporters

A

NE reuptake

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8
Q

predominate on presynaptic memb; inhibit release of NE

A

alpha2 receptors

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9
Q

NE metabolizers

A

MAO, COMT

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10
Q

VMAT

A

Vesicular monoamine transporter (antiport that stores NE into vesicles)

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11
Q

types of adrenoreceptors

A

Alpha (1-2), beta (1-3), dopamine (1-5)

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12
Q

what happens to B affinity as the group on amine group gets larger

A

increases

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13
Q

alpha 1 receptors

A

act via Gq (activation of PLC–>IP3+DAG pathway) –> contraction

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14
Q

alpha 2 receptors

A

act like blockers (but still sympathomimetic)

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15
Q

alpha 2 receptors

A

act via Gi (inhibition of adenylyl cyclase, lower cAMP)

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16
Q

PHENYLEPHRINE, midodrine

A

a1>a2»» b

17
Q

clonidine, methylnorepinephrine

A

a2>a1»» b

18
Q

norepinephrine

A

a1=a2; b1>b2

19
Q

epinephrine

A

a1=a2, b1=b2

20
Q

dobutamine

A

b1 > b2»> a

21
Q

isoprotenerol

A

b2=b1&raquo_space;» a

22
Q

albuterol, terbutaline

A

b2&raquo_space;» b1&raquo_space;» a

23
Q

dopamine

A

D1 = D2&raquo_space;> b&raquo_space;» a

24
Q

fenoldopam

A

D1 > D2

25
Q

dopamine has highest affinity for

A

dopamine receptors (causes renovasodilation)

26
Q

dopamine at a1 receptor

A

vasoconstriction (inc BP)

27
Q

dopamine at B1 receptor

A

increase heart contractility

28
Q

dopamine increase heart contractility

A

medium concentration

29
Q

dopamine inc renal vasodilaiton

A

low concentration

30
Q

non selective Beta blockers

A 
pindolol
timolol
nadolol
pindolol
labetalol
31
Q

B1 selective

A 
acebutolol
betaxolol
esmolol
atenolol
metaprolol
32
Q

partial agonists

A

pindolol, acebutolol

33
Q

non selective alpha and beta

A

carvedilol

labetalol

Ther 201 (6 decks)

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