Adrenergic Agents and Blockers Flashcards
sympathetic
adrenergic
sympathomimetic
adrenergic agonists
sympatholytic
adrenergic ANTAGonists
sympathomimetic
mimic e/norE (catecholamines)
norE
nerve terminals (n:n)
epinephrine
adrEnal mEdulla (eEE)
NE transporters
NE reuptake
predominate on presynaptic memb; inhibit release of NE
alpha2 receptors
NE metabolizers
MAO, COMT
VMAT
Vesicular monoamine transporter (antiport that stores NE into vesicles)
types of adrenoreceptors
Alpha (1-2), beta (1-3), dopamine (1-5)
what happens to B affinity as the group on amine group gets larger
increases
alpha 1 receptors
act via Gq (activation of PLC–>IP3+DAG pathway) –> contraction
alpha 2 receptors
act like blockers (but still sympathomimetic)
alpha 2 receptors
act via Gi (inhibition of adenylyl cyclase, lower cAMP)