Adrenergic Agents and Blockers

Question 1

sympathetic

Answer 1

adrenergic

Question 2

sympathomimetic

Answer 2

adrenergic agonists

Question 3

sympatholytic

Answer 3

adrenergic ANTAGonists

Question 4

sympathomimetic

Answer 4

mimic e/norE (catecholamines)

Question 5

norE

Answer 5

nerve terminals (n:n)

Question 6

epinephrine

Answer 6

adrEnal mEdulla (eEE)

Question 7

NE transporters

Answer 7

NE reuptake

Question 8

predominate on presynaptic memb; inhibit release of NE

Answer 8

alpha2 receptors

Question 9

NE metabolizers

Answer 9

MAO, COMT

Question 10

VMAT

Answer 10

Vesicular monoamine transporter (antiport that stores NE into vesicles)

Question 11

types of adrenoreceptors

Answer 11

Alpha (1-2), beta (1-3), dopamine (1-5)

Question 12

what happens to B affinity as the group on amine group gets larger

Answer 12

increases

Question 13

alpha 1 receptors

Answer 13

act via Gq (activation of PLC–>IP3+DAG pathway) –> contraction

Question 14

alpha 2 receptors

Answer 14

act like blockers (but still sympathomimetic)

Question 15

alpha 2 receptors

Answer 15

act via Gi (inhibition of adenylyl cyclase, lower cAMP)

Question 16

PHENYLEPHRINE, midodrine

Answer 16

a1>a2»» b

Question 17

clonidine, methylnorepinephrine

Answer 17

a2>a1»» b

Question 18

norepinephrine

Answer 18

a1=a2; b1>b2

Question 19

epinephrine

Answer 19

a1=a2, b1=b2

Question 20

dobutamine

Answer 20

b1 > b2»> a

Question 21

isoprotenerol

Answer 21

b2=b1&raquo_space;» a

Question 22

albuterol, terbutaline

Answer 22

b2&raquo_space;» b1&raquo_space;» a

Question 23

dopamine

Answer 23

D1 = D2&raquo_space;> b&raquo_space;» a

Question 24

fenoldopam

Answer 24

D1 > D2

Question 25

dopamine has highest affinity for

Answer 25

dopamine receptors (causes renovasodilation)

Question 26

dopamine at a1 receptor

Answer 26

vasoconstriction (inc BP)

Question 27

dopamine at B1 receptor

Answer 27

increase heart contractility

Question 28

dopamine increase heart contractility

Answer 28

medium concentration

Question 29

dopamine inc renal vasodilaiton

Answer 29

low concentration

Question 30

non selective Beta blockers

Answer 30

``` pindolol timolol nadolol pindolol labetalol ```

Question 31

B1 selective

Answer 31

``` acebutolol betaxolol esmolol atenolol metaprolol ```

Question 32

partial agonists

Answer 32

pindolol, acebutolol

Question 33

non selective alpha and beta

Answer 33

carvedilol | labetalol