Nitrogen Metabolism Flashcards
CMP Synthase activated by …
N-acetylglutamate
Ketogenic AA’s give rise to
Acetoacetate
Phenylalanine Hydroxylase
Phenylalanine —> Tyrosine
What element do Porphyrins bind readily?
Iron
Porphyrins make up Heme
Where does heme synthesis occur?
Liver and Erythrocyte-producing cells of Bone Marrow
AA precursor for Heme?
Glycine
Lead inhibits
ALA Dehydratase
Ferrochelatase
Acetyl CoA —> Biliverdin —> Bilirubin (gets solubilized by what?) —> Heme
Glucuronic acid solubylizes Bilirubin
Precursor AA for Catecholamines (dopamine, etc.)?
Tyrosine
Tyrosine Hydroxylase
Tyrosine —> DOPA
What AA’s does Creatine come from?
Arginine or Glycine
Are high kidney Creatine levels good or bad?
Bad, indicates kidney disease (unless you’re jacked)
PRPP Synthetase
Ribose-5-Phosphate to PRPP
Glutamate, Glycine, Aspartate are involved in ……. Synthesis
Purine synthesis
First Purine made?
IMP
Ribonucleotide Reductase
Gives Deoxy forms of nucleotides
Salvage Pathway
Making nucleotides from bases already present
Hypoxanthine-Guanine Phosphoribosyltransferase
Hyposanthine —> GMP
Hypoxanthine-Guanine Phosphoribosyltransferase
Guanine —> GMP
Adenine Phosphoribosyltransferase
Adenine —> AMP
What are purines degraded to? (IMP, AMP, GMP)
Uric Acid
“Puric Acid”
What condition is caused by excess Uric Acid?
Gout
Allopurinol
Inhibits xanthine oxidase to prevent purines —> Uric Acid
Hydroxyurea
Blocks Ribonucleotide Reductase
