Nitrofurantoina Flashcards

1
Q

mecanismo de accion de nitrofurantoina?

A

degradan el ADN e inhiben la síntesis proteica.

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2
Q

son bactericidas?

A

si

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3
Q

por donde se elimina?

A

via renal

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4
Q

que cubre?

A

RBACILOS (-)Pseudomonas

Bacilos aerobios

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5
Q

que efectos adversos produce?

A

. Neuropatia periferica. Fibrosis pulmonar. Hemolisis

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6
Q

Cuál es la indicación principal de la nitrofurantoina?

A

IVU no complicada.

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7
Q

que otra indicacion tiene?

A

Profilaxis IVU en mujeres

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8
Q

donde se metabolisa?

A

en el higado.

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9
Q

que categoria es en el embarazo?

A

b

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10
Q

Una px. se somete a una mastectomia radical bilateral por la presencia de un cáncer la px. le toman un cultivo de la herida y crece una E. coli solamente sensible a nitrofurantoina. se puede administrar si o no nitrofurantoina y porque?

A

no se aplica, porque no alcanza concentraciones sistémicas, solo se utiliza para tratar IVU.

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11
Q

contraindicaciones…

A

Periparto (no usar 1-2 semanas preparto por riesgo hemolisis).
IVU por Proteus (pH alcalino inactiva nitrofurantoina). Neonatos.
Deficiencia G6PD

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