Nitric oxide Flashcards
1
Q
NO endogenous source
A
oxidation of guanidine group of arginine
2
Q
NO MOA
A
activates guanyl cyclase, increase cGMP, leading to dilation ect
3
Q
NO inhibitors
A
L-arginine derivitives (NMME, and NAME)
7-nitrodiazole and BBS-2 (inhibit NOS)
hemoglobin (NO scavenger)
4
Q
NOS enzymes
A
NOS1: neural, constistutive
NOS2: inducible, in macrophages (responsible for pathologic consequences in sepsis
NOS3: constitutive, endothelium
5
Q
NO donors
A
Amyl nitrate (inhaled, ultra short lasting)
Isosorbide dinatrate
Nitroglycerine (long acting
hydralazine (not in PP but in table)
6
Q
NO interactions
A
Cialis and Viagra….combine effect, get hypotensive crisis
